Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

Hata, Masaharu; Andriessen, Elisabeth M M A; Hata, Maki; Diaz-Marin, Roberto; Fournier, Frédérik; Crespo-Garcia, Sergio; Blot, Guillaume; Juneau, Rachel; Pilon, Frédérique; Dejda, Agnieszka; Guber, Vera; Heckel, Émilie; Daneault, Caroline; Calderon, Virginie; Rosiers, Christine Des; Melichar, Heather J.; Langmann, Thomas; Joyal, Jean‐Sébastien; Wilson, Ariel M.; Sapieha, Przemysław

doi:10.1126/science.abj8894

Cited by 78 publications

(43 citation statements)

References 66 publications

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“…However, the function of these newly found ATMs remains to be understood . Although this study suggests that weight loss promotes beneficial changes to ATMs, two recent papers demonstrate that weight loss induced by switching from high-to low-fat diet does not reverse the obesity-induced inflammatory phenotype of ATMs (Caslin et al, 2022;Hata et al, 2023). Both these studies show that formerly obese ATMs produce more inflammatory cytokines than lean ones, and in comparable amounts to obese ATMs upon stimulation with lipopolysaccharide (LPS).…”

Section: Efferocytosis and Phagocytosismentioning

confidence: 75%

The diverse roles of macrophages in metabolic inflammation and its resolution

Ray

Odum

Wiseman

et al. 2023

Front. Cell Dev. Biol.

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Macrophages are one of the most functionally diverse immune cells, indispensable to maintain tissue integrity and metabolic health. Macrophages perform a myriad of functions ranging from promoting inflammation, through inflammation resolution to restoring and maintaining tissue homeostasis. Metabolic diseases encompass a growing list of diseases which develop from a mix of genetics and environmental cues leading to metabolic dysregulation and subsequent inflammation. In this review, we summarize the contributions of macrophages to four metabolic conditions–insulin resistance and adipose tissue inflammation, atherosclerosis, non-alcoholic fatty liver disease and neurodegeneration. The role of macrophages is complex, yet they hold great promise as potential therapies to address these growing health concerns.

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Section: Efferocytosis and Phagocytosismentioning

confidence: 75%

The diverse roles of macrophages in metabolic inflammation and its resolution

Ray

Odum

Wiseman

et al. 2023

Front. Cell Dev. Biol.

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“…The addition of other components such as hyperglycemia and low-HDL probably serve as precipitating and amplification factors over neuroinflammation. Several publications have begun to describe the relationship between systemic inflammation and neuronal loss [ 72 , 73 , 74 , 75 ]. Briefly, insulin resistance and hyperinsulinic states (such as obesity and hypertriglyceridemia) induce mitochondrial dysfunction in neurons, mitochondrial fission, and energy loss, suggesting that glycemic and lipidic dysmetabolism induce neuronal loss [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

NHANES 2011–2014 Reveals Decreased Cognitive Performance in U.S. Older Adults with Metabolic Syndrome Combinations

Díaz-Camargo

Hernández-Lalinde

Sánchez‐Rubio

et al. 2023

IJERPH

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A relationship between metabolic syndrome and cognitive impairment has been evidenced across research; however, conflicting results have been observed. A cross-sectional study was conducted on 3179 adults older than 60 from the 2011–2014 National Health and Nutrition Examination Survey (NHANES) to analyze the relationship between metabolic syndrome and cognitive impairment. In our results, we found that adults with abdominal obesity, high triglycerides, and low HDL cholesterol had 4.39 fewer points in the CERAD immediate recall test than adults without any metabolic syndrome factors [Beta = −4.39, SE = 1.32, 17.75 (1.36) vs. 22.14 (0.76)]. In addition, people with this metabolic syndrome combination exhibited 2.39 fewer points in the CERAD delayed recall test than those without metabolic syndrome criteria [Beta = −2.39, SE = 0.46, 4.32 (0.49) vs. 6.71 (0.30)]. It was also found that persons with high blood pressure, hyperglycemia, and low HDL–cholesterol levels reached 4.11 points less in the animal fluency test than people with no factors [Beta = −4.11, SE = 1.55, 12.67 (2.12) vs. 16.79 (1.35)]. These findings suggest that specific metabolic syndrome combinations are essential predictors of cognitive impairment. In this study, metabolic syndrome combinations that included obesity, fasting hyperglycemia, high triglycerides, and low HDL–cholesterol were among the most frequent criteria observed.

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“…It indicated no matter developing into obesity status or from obesity to normal weight, as long as obesity had occurred in one's lifespan, blood pressure would be abnormal. Studies have found that this is caused by the hidden danger of immune cell abnormalities during the obesity period ( 24 ). We speculate that this might be due to a large amount of free fatty acids in the circulatory system of obese individuals, and these fatty acids can directly change the innate immune cells including monocytes and macrophages into inflammatory phenotypes, which are retained in the aging process of mice through “epigenetic memory” ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Keeping obesity status is a risk factor of hypertension onset: evidence from a community-based longitudinal cohort study in North China

Cai

Zhang

Dong

et al. 2023

Front. Public Health

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ObjectiveThe purpose of our study was to investigate the association of obesity status change with hypertension onset based on a community-based longitudinal cohort study in North China.MethodsThis longitudinal study included 3,581 individuals free of hypertension at baseline in the first survey (2011–2012). All participants were followed up (2018–2019). According to the criteria, a total of 2,618 individuals were collected for analysis. We used adjusted Cox regression models and Kaplan–Meier survival analysis to estimate the association between obesity status change and hypertension onset. Additionally, we applied the forest plot to visualize the subgroup analysis including age, gender, and the differences in some variables between baseline and follow-up. Finally, we conducted a sensitivity analysis to examine the stability of our results.ResultsOver nearly 7 years of follow-up, a total of 811 (31%) developed hypertension. The new hypertension incidence was mostly observed in those who were obese all the time (P for trend < 0.01). In the fully adjusted Cox regression model, being obese all the time increased the risk of hypertension by 30.10% [HR 4.01 (95% CI 2.20–7.32)]. The Kaplan–Meier survival analysis revealed the change in obesity status as an important feature to predict the occurrence of hypertension. Sensitivity analysis shows a consistent trend between the change in obesity status and hypertension onset in all populations. Subgroup analysis showed that age above 60 years was an important risk factor for hypertension onset, that men were more likely than women to develop hypertension, and that weight control was beneficial in avoiding future hypertension in women. There were statistically significant differences in ΔBMI, ΔSBP, ΔDBP, and ΔbaPWV between the four groups, and all variables, except baPWV changes, increased the risk of future hypertension.ConclusionOur study shows that obese status was notably associated with a significant risk of hypertension onset among the Chinese community-based cohort.

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Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

Cited by 78 publications

References 66 publications

The diverse roles of macrophages in metabolic inflammation and its resolution

The diverse roles of macrophages in metabolic inflammation and its resolution

NHANES 2011–2014 Reveals Decreased Cognitive Performance in U.S. Older Adults with Metabolic Syndrome Combinations

Keeping obesity status is a risk factor of hypertension onset: evidence from a community-based longitudinal cohort study in North China

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