Past, Present and Future of Carotenoids Research

Zia-Ul-Haq, Muhammad

doi:10.1007/978-3-030-46459-2_28

Cited by 13 publications

(15 citation statements)

References 10 publications

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“…Although the mortality rate of coronavirus disease of 2019 (COVID-19) is less than 10% together with smog, the increase in fatality can be observed because both target the respiratory tract of humans [16]. In elderly people, coronavirus invasion is facilitated as immune responses are weakened by age and smog [17]. Together they may worsen the disease and can lead to hospitalization and eventually death occurs [18] as shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

The Potential Impact of Smog Spell on Humans’ Health Amid COVID-19 Rages

Javed

Aamir

Gohar

et al. 2021

IJERPH

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Rapid and unchecked industrialization and the combustion of fossil fuels have engendered a state of fear in urban settlements. Smog is a visible form of air pollution that arises due to the over-emissions of some primary pollutants like volatile organic compounds (VOCs), hydrocarbons, SO2, NO, and NO2 which further react in the atmosphere and give rise to toxic and carcinogenic secondary smog components. Smog reduces the visibility on roads and results in road accidents and cancellation of flights. Uptake of primary and secondary pollutants of smog is responsible for several deleterious diseases of which respiratory disorders, cardiovascular dysfunction, neurological disorders, and cancer are discussed here. Children and pregnant women are more prone to the hazards of smog. The worsening menace of smog on one hand and occurrence of pandemic i.e., COVID-19 on the other may increase the mortality rate. But the implementation of lockdown during pandemics has favored the atmosphere in some ways, which will be highlighted in the article. On the whole, the focus of this article will be on the dubious relationship between smog and coronavirus.

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Section: Introductionmentioning

confidence: 99%

The Potential Impact of Smog Spell on Humans’ Health Amid COVID-19 Rages

Javed

Aamir

Gohar

et al. 2021

IJERPH

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“…The genus Mimosa has been demonstrated to possess various pharmacological activities, including antiseptic, antimicrobial [ 27 , 28 ], antioxidant [ 29 , 30 , 31 , 32 , 33 , 34 ], anticonvulsant [ 35 ], antifertility [ 36 ], antigout [ 37 ], anti-inflammatory [ 38 , 39 , 40 ], antinociceptive [ 41 , 42 ], antiulcer [ 43 ], antimalarial [ 44 ], antiparasitic [ 45 ], antidiabetic [ 46 , 47 ], anticancer [ 48 , 49 ], antidepressant [ 50 ], antidiarrheal [ 51 , 52 ], antihistamic [ 53 ], wound-healing [ 54 ], antispasmolytic [ 55 ], hypolipidemic [ 56 ], hepatoprotective [ 57 ], hypolipidiemic [ 58 ], antivenom [ 40 ], antiproliferative [ 59 ], antiviral [ 60 ], and aphrodisiac activities [ 61 ]. Phytochemicals studies of plants have revealed the presence of secondary metabolites, such as alkaloids, tannins, flavonoids, terpenoids, saponins, steroids [ 62 , 63 ], and coumarins [ 64 ]. The green synthesis of nanoparticles is cheap, simple, comparatively and reproducible, resulting in the production of more stable and useful materials [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

Majeed

Ashar

Rasheed

et al. 2021

IJMS

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The Mimosa genus belongs to the Fabaceae family of legumes and consists of about 400 species distributed all over the world. The growth forms of plants belonging to the Mimosa genus range from herbs to trees. Several species of this genus play important roles in folk medicine. In this review, we aimed to present the current knowledge of the ethnogeographical distribution, ethnotraditional uses, nutritional values, pharmaceutical potential, and toxicity of the genus Mimosa to facilitate the exploitation of its therapeutic potential for the treatment of human ailments. The present paper consists of a systematic overview of the scientific literature relating to the genus Mimosa published between 1931 and 2020, which was achieved by consulting various databases (Science Direct, Francis and Taylor, Scopus, Google Scholar, PubMed, SciELO, Web of Science, SciFinder, Wiley, Springer, Google, The Plant Database). More than 160 research articles were included in this review regarding the Mimosa genus. Mimosa species are nutritionally very important and several species are used as feed for different varieties of chickens. Studies regarding their biological potential have shown that species of the Mimosa genus have promising pharmacological properties, including antimicrobial, antioxidant, anticancer, antidiabetic, wound-healing, hypolipidemic, anti-inflammatory, hepatoprotective, antinociceptive, antiepileptic, neuropharmacological, toxicological, antiallergic, antihyperurisemic, larvicidal, antiparasitic, molluscicidal, antimutagenic, genotoxic, teratogenic, antispasmolytic, antiviral, and antivenom activities. The findings regarding the genus Mimosa suggest that this genus could be the future of the medicinal industry for the treatment of various diseases, although in the future more research should be carried out to explore its ethnopharmacological, toxicological, and nutritional attributes.

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“…As a result, the contractile response in the tissue will not be produced [40], as depicted in computational studies, i.e., kaempferol-3-o-glucoside, ellagic acid, luteolin quercetin, and kaempferol had activities against calcium mediate signaling pathway and intervened with calcium cytosolic concentration. These interaction of bioactive compounds with target genes can cure multiple diseases [41].…”

Section: Discussionmentioning

confidence: 99%

Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway

et al. 2021

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Cucumis sativus L. is globally cultivated as an edible vegetable. Besides its nutritional benefits, it is used in traditional medicines against various ailments. The current study was designed to elucidate the multi-target mechanisms of a C. sativus seeds extract against asthma and diarrhea using network pharmacology along with a molecular docking approach. Furthermore, in-vitro and in-vivo experiments were conducted to verify the mechanistic insight of in silico studies. LC-ESI-MS/MS was performed to identify the bioactive compounds in the extract; later, some compounds were quantified by HPLC. C. sativus seed. EtOH has kaempferol in higher concentration 783.02 µg/g, followed by quercetin (693.83 µg/g) and luteolin (617.17 µg/g). In silico studies showed that bioactive compounds interfered with asthma and diarrhea-associated target genes, which are members of calcium-mediated signaling to exert a calcium channel blocker activity. The seeds extract exerted a concentration-dependent spasmolytic response on isolated jejunum, trachea, and urinary bladder preparations and caused relaxation of spastic contraction of K+ (80 mM) with suppressed calcium concentration-response curves at dose 0.3 and 1 mg/mL. It also showed antiperistalsis, antidiarrheal and antisecretory activity in animal models. Thus, C. sativus seeds have therapeutic effects by regulating the contractile response through a calcium-mediated signaling pathway.

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Past, Present and Future of Carotenoids Research

Cited by 13 publications

References 10 publications

The Potential Impact of Smog Spell on Humans’ Health Amid COVID-19 Rages

The Potential Impact of Smog Spell on Humans’ Health Amid COVID-19 Rages

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway

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