Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer

Abstract

Hyperthermic intraperitoneal chemotherapy (HIPEC), along with optimal cytoreductive surgery, has been debated to be a viable option for the treatment of advanced epithelial ovarian cancer with peritoneal carcinomatosis. HIPEC is associated with a direct and improved penetration of chemotherapy drugs into the affected tissue and is associated with fewer systemic side effects. There is no standard protocol for the use of HIPEC in advanced ovarian cancer. Hence, there is controversy over the timing, dose, duration, and efficacy of HIPEC. In this review, the history, technique, current evidence, recommendations, and future directions of HIPEC are discussed.

Доцільність Застосування Циторедуктивної Хірургії Та Гіпертермічної Внутрішньочеревної Хіміотерапії У Хворих На Рак Яєчника. Дискусійні Аспекти

“…Аналізуючи дані ретроспективного дослідження щодо HIPEC за участю 112 пацієнток із РЯ, яким проведено циторедуктивну хірургію та HIPEC в період 2005-2019 рр., доведено, що результати виживаності однакові у хворих з та без HIPEC. Тому автори наполягають на проведенні рандомізованих досліджень [11].…”

Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy: Analysis of Perioperative Risk Factors and Impact on Outcome

“…Peritoneal carcinomatosis used to be considered a palliative and incurable condition with poor survival rates [1] until 1995, when Sugarbaker et al standardized a surgical approach combined with locoregional chemotherapy, which enabled improvement in quality of life and survival [2]. Over the last decades, cytoreductive surgery (CRS) combined with hyperthermic intraoperative chemotherapy (HIPEC) has evolved as an effective multimodal treatment for selected patients with peritoneal surface malignancies of different origins [3][4][5][6][7]. As any complex procedure, it requires a multidisciplinary and dedicated team and a standard perioperative approach, which includes appropriate patient selection, preoperative optimization, intraoperative protocol, and adequate postoperative care to improve outcomes [8,9].…”

Hyperthermic Intra Peritoneal Chemotherapy (HIPEC)

“…It was first introduced in the year 1980. 1,2 Indications. 4 • Highly suitable when high doses of chemo is required.…”