Pasteurella multocida: from Zoonosis to Cellular Microbiology

Abstract

SUMMARY In a world where most emerging and reemerging infectious diseases are zoonotic in nature and our contacts with both domestic and wild animals abound, there is growing awareness of the potential for human acquisition of animal diseases. Like other Pasteurellaceae , Pasteurella species are highly prevalent among animal populations, where they are often found as part of the normal microbiota of the oral, nasopharyngeal, and upper respiratory tracts. Many Pasteurella species are opportunistic pathogens that can cause endemic disease and are associated increasingly with epizootic outbreaks. Zoonotic transmission to humans usually occurs through animal bites or contact with nasal secretions, with P. multocida being the most prevalent isolate observed in human infections. Here we review recent comparative genomics and molecular pathogenesis studies that have advanced our understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections. We also summarize efforts being explored to enhance our ability to rapidly and accurately identify and distinguish among clinical isolates and to control pasteurellosis by improved development of new vaccines and treatment regimens.

Molecular characterization of Pasteurella multocida isolates from swine lungs by Randomly Amplified Polymorphic DNA

“…The occurrence of P. multocida in other species has also been reported, such as pasteurellosis ('snuffles') in rabbits, fowl cholera in poultry, hemorrhagic septicemia in ruminants and animal scratches and bites in humans (ARUMUGAM et al, 2011;ASHRAF et al, 2011;LÓPEZ et al, 2013;WILSON & HO, 2013RAVAL et al, 2014 (KICH et al, 2007). P. multocida is a Gram-negative bacterium grouped into five capsular serogroups (A, B, D, E and F) and is further classified into 16 somatic serotypes according to the lipopolysaccharide antigen (HEDDLESTON, 1972;PIJOAN, 2006;BOROWSKY et al, 2007).…”

Zoonotic Bacteria Associated with Cats

“…13,14 Cat bites and scratches can result in Pasteurella infections in humans. Pasteurella species are isolated from over 75% of the cat bites .Wilson and Ho 15 and Giordano et al 12 reviewed the clinical features and outcomes of Pasteurella multocida infection in humans. A wide spectrum of diseases from local infections to septic shock can result from Pasteurella infections.…”

Identificação de transcritos diferencialmente expressos por Pasteurella multocida em condições de privação de ferro

“…P. multocida, assim como outras bactérias, desenvolveu mecanismos básicos para adquirir Fe através de agentes quelantes (sideróforos) que captam o Fe de hidróxidos férricos ou por receptores a partir de proteínas do hospedeiro (Jacques et al 1994, Wilson & Ho 2013. O sequenciamento do genoma de P. multocida Pm70 revelou que 2,5% do genoma da bactéria correspondem a 53 proteínas codificadas similares às envolvidas no metabolismo do Fe .…”