Patch test clinic experience of potential cross‐reactivity of isothiazolinones

Craig, Sarah; Urwin, Rachel; Latheef, Faheem; Wilkinson, S. M.

doi:10.1111/cod.12741

Cited by 21 publications

(30 citation statements)

References 5 publications

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“…This confirms the former experience that MI allergy is a risk factor in the development of polysensitization. This observation and the possibility of cross‐reactions between MI, MCI, and other isothiazolinones render this topic important also in the future …”

Section: Discussionmentioning

confidence: 99%

Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone hypersensitivity in 1122 patients: A national multicenter study organized by the Hungarian Contact Dermatitis Group

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone hypersensitivity in 1122 patients: A national multicenter study organized by the Hungarian Contact Dermatitis Group

et al. 2019

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“…Animal data and more recent epidemiological studies have posited cross‐reactivity between MI and MCI. Indeed, up to 72% of MI‐sensitized patients show patch test reactions to MCI/MI . In many cases, relevant exposure to MI‐containing products could be shown, with cross‐reactivity suggested .…”

Section: Cross‐reactivity Vs Concomitant Sensitizationmentioning

confidence: 99%

“…Concerning BIT, considered to be the least sensitizing derivative, co‐sensitization or cross‐reactivity to other isothiazolinones, and particularly to MI, has been less frequently observed . Indeed, patch tests have proved positive irrespective of reactivity to other isothiazolinones.…”

Section: Cross‐reactivity Vs Concomitant Sensitizationmentioning

confidence: 99%

“…Indeed, up to 72% of MI-sensitized patients show patch test reactions to MCI/ MI. 42,93 In many cases, relevant exposure to MI-containing products could be shown, with cross-reactivity suggested. 92 On the other hand, analyses using reconstructed human epidermis model revealed that the probability of cross-reactivity between MI and MCI proves rather low, due to the chlorine atom present in MCI.…”

Section: Cross-reactivity Vs Concomitant Sensitizationmentioning

confidence: 99%

“…7 Concerning BIT, considered to be the least sensitizing derivative, co-sensitization or cross-reactivity to other isothiazolinones, and particularly to MI, has been less frequently observed. 93 Indeed, patch tests have proved positive irrespective of reactivity to other isothiazolinones. Its chemical structure clearly differs from MI, whereas OIT may be considered a chemical homologue of MI, which may account for the more frequently observed concomitant reactions to MI and OIT.…”

Section: Cross-reactivity Vs Concomitant Sensitizationmentioning

confidence: 99%

See 2 more Smart Citations

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Herman

Aerts

Montjoye

et al. 2019

Acad Dermatol Venereol

112

115

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Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in the 1980s, and more recently to MI, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave‐on products, while restricting that in rinse‐off cosmetics. Despite a decreasing prevalence of ACD from MCI/MI and MI, cases caused by occupational exposure and non‐cosmetic isothiazolinone sources are on the rise. Moreover, sensitization to newer and lesser known isothiazolinones has been reported. This paper reviews the epidemiology of contact allergy to different isothiazolinones, clinical presentation of isothiazolinone‐induced ACD, most relevant sensitization sources and potential cross‐reactions between isothiazolinone derivatives. It also provides an update on recent legislative measures.

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Allergic Contact Dermatitis

Orton,

Stone

2024

Rook's Textbook of Dermatology

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Allergic contact dermatitis is considered to be a prototype of delayed hypersensitivity reactions requiring two phases – induction and elicitation. The amount of allergen per skin surface area is the key factor that determines the risk of induction. Exposure‐related factors that influence the elicitation phase include allergen concentration (dose), duration and frequency of exposure, the matrix, the presence of irritants and the region of application. A diagnosis of allergic contact dermatitis requires careful evaluation of a patient's clinical history when the suspicion is aroused, physical examination, and various types of skin testing (patch testing, photopatch testing and repeat open application tests. During the last few decades much effort has been put into standardisation of allergens, vehicles, test concentrations and the scoring of test reactions. This chapter provides information on the diagnosis and management of allergic contact dermatitis and information on the major allergens involved in regional dermatitis.

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Patch test clinic experience of potential cross‐reactivity of isothiazolinones

Cited by 21 publications

References 5 publications

Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone hypersensitivity in 1122 patients: A national multicenter study organized by the Hungarian Contact Dermatitis Group

Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone hypersensitivity in 1122 patients: A national multicenter study organized by the Hungarian Contact Dermatitis Group

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Allergic Contact Dermatitis

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