Patch testing with cobalt in children and adolescents: North American contact dermatitis group experience, 2001–2018

Silverberg, Jonathan I.; Patel, Nisha; Warshaw, Erin M.; Maibach, Howard I.; Belsito, D.; DeKoven, Joel G.; Zug, Kathryn A.; Taylor, James S.; Sasseville, Denis; DeLeo, Vincent A.; Pratt, Melanie D.; Reeder, Margo J.; Atwater, Amber Reck; Fowler, Joseph F.; Houle, Marie‐Claude

doi:10.1111/cod.14185

Cited by 4 publications

(4 citation statements)

References 55 publications

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“…Cobalt chloride, the second most common sensitizing metal, usually causes ACD via contact with jewellery, other metal elements in clothing and cement 32 . As nickel sensitization will eventually decline, cobalt will become the primary sensitizer, compelling authorities to consider regulatory actions.…”

Section: Discussionmentioning

confidence: 99%

“…Cobalt chloride, the second most common sensitizing metal, usually causes ACD via contact with jewellery, other metal elements in clothing and cement. 32 As nickel sensitization will eventually decline, cobalt will become the primary sensitizer, compelling authorities to consider regulatory actions. Other metals OEBS provoked a positive relevant reaction when examined in the suitable clinical scenario, demonstrating a relatively high SPIN.…”

Section: Metalsmentioning

confidence: 99%

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Trends in contact sensitization, results, and implications from a contact dermatitis clinic in Israel

Slodownik,

Bar,

Daniely

2024

Contact Dermatitis

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BackgroundThe baseline series includes common allergens, evolves over time, and differs by location. Our study aims to characterize allergen sensitization trends among the Israeli population during the last two decades, compare our results to American and European registries, as well as to highlight significant allergens in additional series outside the European baseline series (OEBS).MethodsWe analysed patch test results of 2086 patients from a designated contact dermatitis clinic in Tel Aviv between 2019 and 2022, compared them to European and North American registries and to 2156 patch test results conducted in Israel two decades ago.Results38.6% of patients had at least one positive reaction to an allergen in the European baseline series (EBS), Nickel sulphate (14.6%), Fragrance mix I (4.6%), and Methylchloroisothiazolinone methylisothiazolinone (MCI/MI; 3.7%) were the most common among them. N‐Isopropyl N‐Phenyl‐4‐Phenylenediamine (NIPPD; 0%), Propolis (0.1%), Sesquiterpene lactone mix (0.1%), and Budesonide (0.1%) elicited a sensitization frequency significantly lower than the proposed threshold for baseline inclusion. Chi‐square test revealed a statistically significant decrease (p < 0.05) in the sensitization frequency of Fragrance mix 1, Formaldehyde, Potassium dichromate, Neomycin sulphate, Myroxylon pereirae, Sesquiterpene lactone, and NIPPD during the last two decades. The overall sensitization frequency to the majority of allergens was lower in our cohort in comparison to the North American and European registries.ConclusionsMCI/MI and 2‐hydroxyethyl methacrylate‐2 (HEMA) are common, relevant allergens, with high SPIN (significance and prevalence index number) and should be better regulated by the authorities. While among the EBS, NIPPD, Propolis, Sesquiterpene lactone, and Budesonide usually do not elicit a positive reaction and therefore should be reconsidered in baseline series, among the OEBS, Chloramphenicol, Quaternium 15, Propyl gallate, and Amerchol L101 have elicited high SPIN values and should be vigilantly examined in the suitable clinical scenario. Significantly lower sensitization frequency to propolis raises the possibility of a protective effect due to early oral exposure among the Israeli population.

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Section: Discussionmentioning

confidence: 99%

Section: Metalsmentioning

confidence: 99%

Trends in contact sensitization, results, and implications from a contact dermatitis clinic in Israel

Slodownik,

Bar,

Daniely

2024

Contact Dermatitis

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“…Traditional sources of nickel and cobalt exposure, including hairdressing tools, cement, concrete and mortar continue to be reported [14,15]. Chromium continues to be a source of occupational exposure in cement and leather products.…”

Section: Metalsmentioning

confidence: 99%

New causes of occupational allergic contact dermatitis

Clynick,

Holness

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Occupational allergic contact dermatitis (OACD) is an important work-related skin disease. Information about the causative agents comes from many sources, including patch test databases, registries, case series and case reports. This review summarizes new information about common causative allergens and diagnosis. Recent findings Common causes of OACD include rubber components, epoxies and preservatives. New exposure sources for these allergens continue to be described. Often these exposure sources are related to the changing world around us, such as allergens related to smartphones and technology, and personal protective equipment-related exposures during the COVID-19 pandemic. New allergens are also being described, some of which are related to known allergens (e.g. a new epoxy or acrylate component). Accurate diagnosis is critical to effective management of OACD, which may include removing the worker from exposure to the causative allergen. Safety data sheets may not contain complete information and patch testing with specialized series of allergens and workplace materials may be necessary. Summary This review provides current evidence about causes of OACD and important aspects of diagnosis. This is important for clinical practice to ensure cases of OACD are not missed.

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“…In a group of 1919 children, 6% had an allergic reaction to cobalt (Co). ACD triggered by Co should be suspected with dermatitis in a diffused generalized distribution, trunk, or face [ 9 ].…”

Section: Exposurementioning

confidence: 99%

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Zemelka‐Wiącek¹

2022

JCM

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Metal allergy is mainly an environmental disorder which can cause allergic contact dermatitis. Environmental metal exposures include jewelry, everyday metal items, mobile phones, leather, metal-rich food and implants, including stents or anchors. While consumer exposure is liable for the majority of metal hypersensitivity cases, the significance of occupational exposure to metals remains relevant. Although the most common metal allergens are nickel, chromium, and cobalt; however, lately, gold, palladium, titanium, and some others have also attracted attention. This review highlights advances in metal allergy mechanisms, biomarkers for potential patients’ stratification as well as biological treatments. The most recent evidence of human exposure to metal for risk assessment is discussed, as well as the relationship between the occurrence of metal hypersensitivity and implanted devices, including non-characteristic symptoms. The latest data on the diagnosis of metal hypersensitivity are also reported.

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Patch testing with cobalt in children and adolescents: North American contact dermatitis group experience, 2001–2018

Cited by 4 publications

References 55 publications

Trends in contact sensitization, results, and implications from a contact dermatitis clinic in Israel

Trends in contact sensitization, results, and implications from a contact dermatitis clinic in Israel

New causes of occupational allergic contact dermatitis

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

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