2017
DOI: 10.1097/der.0000000000000327
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Patch Testing with Decyl and Lauryl Glucoside: How Well Does One Screen for Contact Allergic Reactions to the Other?

Abstract: Sixty-five percent of glucoside-allergic patients exhibited co-reactions to decyl and lauryl glucosides. Thus, neither glucoside is an adequate screen for allergy to the other. Given that these reactions are often relevant, clinicians should patch test with decyl, lauryl, and other alkyl glucosides in cases of suspected cosmetic allergy.

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Cited by 15 publications
(12 citation statements)
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“…This may be due to cross‐sensitivity due to structural similarities, or concomitant sensitization as they are often present in the same products. A recent study suggested that both surfactants need to be tested to optimize detection of ACD 4 . We agree that the rate of concomitant reactions is not high enough to test only one screening glucoside in the baseline series.…”
Section: Category/ Subcategory Dg Only Lg Only Either or Bothsupporting
confidence: 54%
“…This may be due to cross‐sensitivity due to structural similarities, or concomitant sensitization as they are often present in the same products. A recent study suggested that both surfactants need to be tested to optimize detection of ACD 4 . We agree that the rate of concomitant reactions is not high enough to test only one screening glucoside in the baseline series.…”
Section: Category/ Subcategory Dg Only Lg Only Either or Bothsupporting
confidence: 54%
“…Glucosides are structurally similar, primarily differing by alkyl chain length (DG: 10 carbons, LG: 12 carbons, CG: 10–16 carbons, CeG: 16–18 carbons) 3 . Importantly commercial sources of glucosides are often mixtures of glucosides.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, this substance was identified as a putatively important contact allergen needing further investigation [ 177 ]. Of note, screening to alkyl glucoside surfactants is not possible by using just one of the derivatives, as demonstrated by a study with 48 patients reacting either to decyl or lauryl glucoside (with 41% definite or probable relevance), but only 65% of the patients reacted to both derivatives [ 178 ].…”
Section: Resultsmentioning
confidence: 99%