Patchy Blastomatous Infiltration of the Central Nervous System (Patchy Schwannosis?)

Ferraro, Armando; Jervis, George A.; Sherwood, W. D.

doi:10.1097/00005072-194307000-00002

Cited by 15 publications

(3 citation statements)

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“…Historically, two schools of thought have contended as to whether gliomatosis cerebri represents a dysgenetic, &dquo;blastomatous&dquo; process20, 22,26,[38][39][40]43,45 or a neoplastic proliferation. Nevin2° hypothesized that this proliferation could not have arisen in one location and spread directly as a single tumor formation.…”

Section: Discussionmentioning

confidence: 99%

Gliomatosis Cerebri Presenting as Intractable Epilepsy During Early Childhood

et al. 1995

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We review 160 cases of gliomatosis cerebri from the literature and report an additional three infants and young children who presented with intractable epilepsy, corticospinal tract deficits, and developmental delay in whom a pathologic diagnosis was made. The progressive nature of the encephalopathy in our cases was documented by serial clinical examination, electroencephalograms, magnetic resonance imaging, and positron emission tomographic scans. The natural history of gliomatosis cerebri was determined by a retrospective review of the literature of 160 cases in 85 reports. The most common neurologic symptoms and signs included corticospinal tract deficits (58%), dementia/mental retardation (44%), headache (39%), seizures (38%), cranioneuropathies (37%), increased intracranial pressure (34%), and spinocerebellar deficits (33%). The most commonly involved central nervous system structures were the centrum semiovale and cerebrum (76%), mesencephalon (52%), pons (52%), thalamus (43%), basal ganglia (34%), and the cerebellum (29%). Fifty-two percent of patients were dead within 12 months of onset. Different grades of glial neoplasm may also coexist within gliomatosis cerebri such as astrocytoma with anaplastic astrocytoma, atypical or anaplastic oligodendroglioma, and glioblastoma multiforme. Hypotheses regarding the pathogenesis of gliomatosis cerebri include blastomatous dysgenesis, diffuse infiltration, multicentric origin, in situ proliferation, and "field transformation." The biologic determinants of whether a transformed glial cell behaves as a relatively localized tumor mass or truly loses anchorage dependence to become migratory as well as proliferative are not understood.

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Section: Discussionmentioning

confidence: 99%

Gliomatosis Cerebri Presenting as Intractable Epilepsy During Early Childhood

et al. 1995

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“…Nevin [ 16], Moore [ 17], Kawano et al [20], Yamamoto et al [28], Schmidbauer et al [31], Sarhaddi et al [34] and Ferraro et al [50] reported cases with spinal involvement. Sarhaddi et al [34] reported a case of spinal astrogliosis without neoplasia.…”

Section: Discussionmentioning

confidence: 99%

A Serial CT Scan and MRI Verification of Diffuse Cerebrospinal Gliomatosis: A Case Report with Stereotactic Diagnosis and Radiological Confirmation

Önal

Bayindir²,

Şiraneci³

et al. 1996

Pediatr Neurosurg

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Gliomatosis cerebri is an infrequent tumor of neuroepithelial origin presenting with deterioration of cognitive functions, behavioral and mental changes, motor weakness, headache, and seizures. Laboratory data are unconclusive. MRI appears to be the imaging modality of choice and mainly reveals a bilateral and diffuse infiltration of midline adjacent brain structures whose anatomical configuration remain intact. MRI- or CT-guided stereotactic biopsy is advised as the diagnostic procedure in suspected cases. A 9-year-old girl with diffuse cerebrospinal gliomatosis, investigated with sequential cranial CT scans, and MRI-verified spinal cord involvement is reported, and the corresponding literature is reviewed.

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“…Kawano et al, 18 Yamamoto et al, 19 Schmidbauer et al, 20 Ferraro et al, 21 Finally, inconclusive symptoms, noninformatory laboratory data, nonspecific changes on CT, and the usual isointense to hypointense images on T1-and diffuse high signal intensity on T2-weighted images on MRI -in at least two, but often three lobes of the brain with extension into the…”

Section: If the Final Destination For The Clinician Is Diagnosis Difmentioning

confidence: 99%