Patent duktus arteriozuslu bebeklerde konservatif tedavinin sonuçları

Abstract

The aim of this study is to investigate frequency of patent ductus arteriosus (PDA) according to gestational week, spontaneous closure rate and effectiveness of oral treatment in closure in premature infants. Materials and Methods: Patients who had only PDA in neonatal intensive care unit in 2013-2016 were retrospectively screened and 231 patients included in the study. The demographic data of the patients were recorded and they were divided into groups according to gestational week; size and gradient of PDA. Left atrium/aorta ratio and left ventricular functions were evaluated echocardiographically in 4.6±1.5th day of birth. Results: The frequency of PDA in our neonatal intensive care unit was 10.8% (231/2127 patients). Significant PDA was present in 41(17.7%) of patients, mean diameter of ductus was 2.5±0.5 and the left atrium/aorta ratio was 1.37±0.15 in these patients. Ibuprofen (po) was given to 8(19.5%) of the patients having hemodynamically significant PDA. All of the patients given medical closure treatment were <32 weeks of gestation and <1500g. Surgical closure was required in only one patient. Conclusion: It is still controversial that PDA closure treatment should be given when and to which preterm infants. As only one of the patients needed surgery with the conservative approach, we suggest that treatment decision should not be given early in premature infants with PDA and they should be closely monitored.