Patent Foramen ovale, Stroke and Paradoxical Embolism

Mas, Jean‐Louis

doi:10.1159/000108840

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…The results of this study confirm the conclusions of a number of prestigious researchers [7,12,13,16,17,21,22,23,28] as to the relevance of a PFO as a causal mechanism of focal cerebral ischemia in young subjects. In addition, TTcEC seems to be an accurate (specificity= 97%; sensitivity = 83% [29]; specificity = 100%; sensitivity 47% [8]) low-risk diagnostic technique in comparison with TEcEC.…”

Section: Discussionsupporting

confidence: 90%

Focal cerebral ischemia and patent cardiac foramen ovale

et al. 1994

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By means of transthoracic contrast echocardiography, the prevalence of a patent foramen ovale (PFO) was studied, in a continuous series of 48 patients aged less than 50 years with a recent episode of acute cerebral ischemia. A PFO was found in 11 subjects (23%). In the subgroup of younger patients (aged less than 30 years), the prevalence was much higher than in those aged 30 or more (58% against 11%, p = 0.0022). In the 19 patients with clear evidence of extracardiac causal factors of cerebral ischemia, there was no PFO; of the remaining 29 subjects, a PFO was present in 11 (38%) (p = 0.0015). In conclusion, the possible presence of a PFO must be carefully investigated in subjects with cerebral ischemia aged less than 30, as well as in subjects aged between 30 and 50 in whom there is no acceptable explanation for their cerebral ischemic episode.

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Section: Discussionsupporting

confidence: 90%

Focal cerebral ischemia and patent cardiac foramen ovale

et al. 1994

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“…Occult sources of emboli are often suspected to be respon sible for IUC [5. 6], IUC may account for up to 40% of all cerebral infarcts [4], and it may be im portant to investi- gate the occurrence of paradoxical embolism as one possi ble mechanism of cryptogenic stroke [7][8][9], TCD has an established role in the investigation of acute-stroke patients [10]. TCD has been used as an im portant tool, not only for diagnosis and follow-up of stroke patients, but also for m onitoring those patients during intensive-care treatm ent or surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Detection of Paradoxical Cerebral Embolism Using Transcranial Doppler in a Patient with Infarct of Undetermined Cause

et al. 1993

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A 35-year-old man presented with acute aphasia and a left parietal infarction demonstrated by magnetic resonance imaging. He did not have an obvious etiology for stroke except for a patent foramen ovale detected by contrast echocardiography. A simultaneous transcranial Doppler ultrasound examination detected microbubbles in the middle cerebral artery. A deep venous thrombus was also detected. It is presumed that a paradoxical embolization occurred through a patent foramen ovale with target organ involvement demonstrated by the transcranial Doppler study. Transcranial Doppler may be used to detect paradoxical embolism in patients with acute stroke of undetermined cause.

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