Has Australia’s focus as a producer and exporter of natural resources—often considered low technology industries—constrained the development of its innovation system? We exploit a new digital database from the Commonwealth Patent Office to investigate this question. We find that the focus of domestic innovativeness supported key industries for Australian development and complemented technological specialization by foreign patent applicants, particularly in European and American manufacturing. The results support the argument that shifts in national technological orientation is a relatively long game and that technical advantage is shaped by a nation’s stage of economic development.