Paternal age and assisted reproductive technology outcome in ovum recipients

Luna, M.; Finkler, Elissa; Barritt, J.; Bar‐Chama, Natan; Sandler, B.; Copperman, A.B.; Grunfeld, L.

doi:10.1016/j.fertnstert.2009.05.036

Cited by 114 publications

(132 citation statements)

References 18 publications

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“…Some studies from Europe and USA found that the increase of male age may lead to elevation of miscarriage rate after ART [4,[11][12][13]. We also found that male aging may be related to the increase of pregnancy loss in the first trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 62%

“…Also, when the cycles were divided into two groups according to whether a clinical pregnancy was achieved, or according to whether a live birth was achieved, no significant difference was found in male age between the groups, indicating that male aging would not lead to severe influence on fertilization or embryo development in vitro, which was similar to studies of other authors [8][9][10], but disagreed with founding of other authors [11,12].…”

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

Zhang

Yin

et al. 2012

J Assist Reprod Genet

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Section: Discussionsupporting

confidence: 62%

Section: Discussioncontrasting

confidence: 59%

Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

Zhang

Yin

et al. 2012

J Assist Reprod Genet

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“…[18][19][20][21][22][23][24][25][26][27][28] Although embryo quality at the cleavage stage (days 2-3) was not affected by increasing males' age, it was associated with a significant decrease in blastocyst embryo formation, probably reflecting male genomic activation within the embryo.…”

Section: Reproductive Outcome In In Vitro Fertilization (Ivf)mentioning

confidence: 99%

Advanced paternal age and reproductive outcome

Wiener-Megnazi¹,

Auslender²,

Dirnfeld³

2011

Asian J Androl

102

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Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.

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“…Additionally, Robertshaw et al found a significantly low live birth rate with IVF for elder men (decreased by 26 % for each 5-year increase in paternal age) [102]. Two studies have indicated that fertilization rates and blastocyst formation rates significantly decreased, and pregnancy loss increased with ART in men older than 50 years [103,104]. A retrospective analysis of 4887 oocyte donation cycles has demonstrated no differences in biochemical, clinical, and ongoing pregnancies, miscarriage, and live birth rates among different male age groups [105].…”

Section: Fertilization Capacitymentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

195

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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Paternal age and assisted reproductive technology outcome in ovum recipients

Cited by 114 publications

References 18 publications

Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

Advanced paternal age and reproductive outcome

Effects of aging on the male reproductive system

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