Paternal age, body mass index, and semen volume are associated with chromosomal aberrations-related miscarriages in couples that underwent treatment by assisted reproductive technology

Abstract

We investigated the effects of paternal characteristics, including age, body mass index (BMI), and semen parameters on chromosomal aberration-related miscarriages in couples that underwent treatment with assisted reproductive technology (ART). Single nucleotide polymorphism (SNP) array analysis showed chromosomal aberrations in 60.2% (557/925) of miscarried fetuses, including trisomy in 73.1% (407/557) of cases. There were higher chromosomal aberration rates in fetuses for men aged 20-24 years and ≥30 years compared with controls. After adjusting for age and BMI of the female partners, and the BMI and semen parameters of the males, there was no statistically significant effect of paternal age ≥30 years on the risk of chromosomal aberrations-related miscarriages. However, the odds of chromosomal abnormality-related miscarriage were 148% higher for the youngest fathers (age: 20-24 years) than fathers aged 25-29 years [adjusted odds ratio (OR): 2.48, 95% confidence interval (CI): 1.03-5.96; P=0.042]. Furthermore, high male BMI (adjusted OR: 1.56, 95% CI: 1.14-2.14; P=0.005) and low semen volume (adjusted OR: 2.09, 95% CI: 1.06-4.11; P=0.034) were associated with increased risk of chromosomal aberration-related miscarriages. These findings demonstrate that very young paternal age, high BMI, and low semen volume are associated with increased risk of chromosomal aberration-related miscarriages in couples undergoing ART treatment.

Relationship between paternal factors and embryonic aneuploidy of paternal origin

“…Paternal obesity is associated with decreased sperm concentration and motility, decreased clinical pregnancy and live birth rates, and increased sperm deoxyribonucleic acid (DNA) fragmentation (9,(17)(18)(19). Few studies assess the relationship between paternal BMI and embryonic aneuploidy, and to our knowledge no studies have assessed the direct relationship between paternal BMI and embryonic aneuploidy of paternal origin (20). With rapidly increasing rates of obesity, information on its link to male reproduction is growing in importance.…”

Effect of previous Chlamydia Trachomatis infection on the outcomes of ivf/icsi treatment: a retrospective study

“…Previous studies demonstrated relative factors which can become potential confounders in this study [ 16 , 17 ]. The univariate analysis showed live birth rate was associated with age, BMI, infertility duration, initial dose of Gn, total dose of Gn, level of E 2 , approach of fertilization and whether CT infection or not (P < 0.1) (Table 4 ).…”

Independent value of serum β-human chorionic gonadotropin in predicting early pregnancy loss risks in IVF/ICSI cycles

“…Wang et al. discovered that in couples undergoing ART therapy, a relatively young paternal age was associated with an increased risk of chromosomal aberration-related miscarriages ( 33 ). Most previous studies ( 31 , 32 ) concluded that paternal age did not affect the EPL rate after IVF/ICSI.…”