Paternal ageing impacts blastulation and the outcomes of pregnancy at different levels of maternal age: A clustering analysis of 21,960 oocytes and 3837
            <scp>ICSI</scp>
            cycles

Setti, Amanda Souza; Braga, Daniela Paes de Almeida Ferreira; Guilherme, Patrı́cia; Vingris, Livia; Iaconelli, Assumpto; Borges, Edson

doi:10.1111/and.14485

Cited by 3 publications

(1 citation statement)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, spermatological tests of 16‐ to 72‐year old individuals revealed a decrease in spermatogenesis after the age of 34 years 27 ; furthermore, in vitro fertilization, implantation, pregnancy, and fertility rates decline with each additional year of age in males. 28 However, a few studies have focused on the effect of aging on spermatogenesis in laboratory animals such as mice. We show that spermatogenesis decreased at 90 weeks of age in C57BL/6J mice.…”

Section: Discussionmentioning

confidence: 99%

KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction

Kuribayashi,

Fukuhara,

Kitakaze

et al. 2024

Reprod Medicine & Biology

View full text Add to dashboard Cite

PurposeThe average fatherhood age has been consistently increasing in developed countries. Aging has been identified as a risk factor for male infertility. However, its impact on various mechanisms remains unclear. This study focused on the KEAP1–NRF2 oxidative stress response system, by investigating the relationship between the KEAP1–NRF2 system and age‐related changes in spermatogenesis.MethodsFor examination of age‐related changes, we used 10‐, 30‐, 60‐, and 90‐week‐old mice to compare sperm count, sperm motility, and protein expression. For assessment of Keap1 inhibition, 85‐week‐old C57BL/6J mice were randomly assigned to the following groups: control and bardoxolone methyl (KEAP1 inhibitor). Whole‐exome sequencing of a Japanese cohort of patients with non‐obstructive azoospermia was performed for evaluating.ResultsSperm count decreased significantly with aging. Oxidative stress and KEAP1 expression in the testes were elevated. Inhibition of KEAP1 in aging mice significantly increased sperm count compared with that in the control group. In the human study, the frequency of a missense‐type SNP (rs181294188) causing changes in NFE2L2 (NRF2) activity was significantly higher in patients with non‐obstructive azoospermia than in healthy control group.ConclusionsThe KEAP1–NRF2 system, an oxidative stress response system, is associated with age‐related spermatogenesis dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction

Kuribayashi,

Fukuhara,

Kitakaze

et al. 2024

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

Total blastocyst usable rate is a predictor of cumulative live birth rate in IVF cycles

Chaillot,

Reignier,

Fréour

2024

Journal of Gynecology Obstetrics and Human Reproduction

View full text Add to dashboard Cite

Is paternal age associated with transfer day, developmental stage, morphology, and initial hCG-rise of the competent blastocyst leading to live birth? A multicenter cohort study

et al. 2022

View full text Add to dashboard Cite

In this study we investigated whether age of men undergoing assisted reproductive technology (ART) treatment was associated with day of transfer, stage, morphology, and initial hCG-rise of the competent blastocyst leading to a live birth? The design was a multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial hCG-rise) from men whose partner underwent single blastocyst transfer resulting in singleton pregnancy/birth. The ART treatments were carried out at sixteen private and university-based public fertility clinics. We included 7246 men and women, who between 2014 and 2018 underwent controlled ovarian stimulation (COS) or Frozen-thawed Embryo Transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. 4842 men with a partner giving birth were included, by linking data to the Danish Medical Birth Registry. We showed that the adjusted association between paternal age and transfer day in COS treatments was OR 1.06, 95% CI (1.00;1.13). Meaning that for every increase of one year, men had a 6% increased probability that the competent blastocyst was transferred on day 6 compared to day 5. Further we showed that the mean difference in hCG values when comparing paternal age group 30–34, 35–39 and 40–45 with the age group 25–29 in those receiving COS treatment, all showed significantly lower adjusted values for older men. In conclusion we hypothesize that the later transfer (day 6) in female partners of older men may be due to longer time spent by the oocyte to repair fragmented DNA of the sperm cells, which should be a focus of future research in men.

show abstract

Paternal ageing impacts blastulation and the outcomes of pregnancy at different levels of maternal age: A clustering analysis of 21,960 oocytes and 3837 ICSI cycles

Cited by 3 publications

References 59 publications

KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction

KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction

Total blastocyst usable rate is a predictor of cumulative live birth rate in IVF cycles

Is paternal age associated with transfer day, developmental stage, morphology, and initial hCG-rise of the competent blastocyst leading to live birth? A multicenter cohort study

Contact Info

Product

Resources

About