Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

Öst, Anita; Lempradl, Adelheid; Casas, Eduard; Weigert, Melanie; Tiko, Theodor; Deniz, Merdin; Pantano, Lorena; Boenisch, Ulrike; Itskov, Pavel M.; Stoeckius, Marlon; Ruf, Marius; Rajewsky, Nikolaus; Reuter, Günter; Iovino, Nicola; Ribeiro, Carlos; Alenius, Mattias; Heyne, Steffen; Vavouri, Tanya; Pospisilik, J. Andrew

doi:10.1016/j.cell.2014.11.005

Cited by 363 publications

(265 citation statements)

References 73 publications

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“…Recent data from both animals and plants indicate that epigenetic resetting is not always complete and hence that acquired epigenetic states may be transmitted from parents to offspring ('germ-line epigenetic inheritance' or 'incomplete epigenetic resetting' or 'incomplete epigenetic reprogramming'; e.g. [6][7][8][9][10][11][12][13][14] reviewed in [4,5,[15][16][17][18][19]). …”

Section: Introductionmentioning

confidence: 99%

When is incomplete epigenetic resetting in germ cells favoured by natural selection?

2015

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Resetting of epigenetic marks, such as DNA methylation, in germ cells or early embryos is not always complete. Epigenetic states may therefore persist, decay or accumulate across generations. In spite of mounting empirical evidence for incomplete resetting, it is currently poorly understood whether it simply reflects stochastic noise or plays an adaptive role in phenotype determination. Here, we use a simple model to show that incomplete resetting can be adaptive in heterogeneous environments. Transmission of acquired epigenetic states prevents mismatched phenotypes when the environment changes infrequently relative to generation time and when maternal and environmental cues are unreliable. We discuss how these results may help to interpret the emerging data on transgenerational epigenetic inheritance in plants and animals.

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Section: Introductionmentioning

confidence: 99%

When is incomplete epigenetic resetting in germ cells favoured by natural selection?

2015

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“…The F 2 and subsequent generations may also be affected, depending on the proximate mechanism that mediates transmission across generations [32]. These mechanisms are still poorly understood, but there is evidence in flies of transmission via changes in chromatin structure [47]. If such an effect does persist for one or more generations, then demographic consequences may result.…”

Section: Resultsmentioning

confidence: 99%

Effect of Psychoactive Drugs on Demographic Parameters of the Blow Fly Chrysomya albiceps (Wiedemann) (Diptera: Calliphoridae)

Gião¹,

Reigada²,

Moretti³

et al. 2017

J Forensic Res

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Knowledge of the factors influencing the ecology of blow flies, especially the dynamic population equilibrium, is essential in forensic entomology. However, lack of knowledge of the action of psychoactive drugs on the population dynamics of these flies may affect the inferences that experts must make in medico-legal reports. This study evaluated the effects of amphetamine and phenobarbital on the population dynamics of Chrysomya albiceps (Wiedemann), by combining laboratory experimentation and mathematical modelling. Only amphetamine and its control, methanol, influenced the qualitative dynamic behaviour of Chrysomya albiceps, stabilising chaotic populations. The results are discussed in an ecological and forensic context. may, when combined with phenobarbital, enhance its action [18]. Barbiturates ranked in second place among the drugs used in suicide attempts in the state of Goiás, Central-West Brazil, in 2003-2004.Blow flies (Diptera: Calliphoridae) are among the first insects to perceive and colonise vertebrate remains [2,21]. Chrysomya albiceps (Wiedemann) originated in the Old World tropics, and over time spread around the world, reaching Brazil in 1975Brazil in or 1976. The species is of major forensic importance, allowing the estimation of the PMI min [21] and also the detection of ante-mortem use of drugs and toxins [24]. The establishment of Chrysomya species in Brazil affected the dynamic behaviour of native blow flies, causing the decline of populations of Cochliomyia macellaria (Fabricius) and, to a lesser extent, Lucilia eximia (Wiedemann) [25].Calliphorid flies breed in discrete generations, displaying high sensitivity in demographic parameters influenced by larval density, which are usually closely associated with population equilibrium [25]. Mathematical models involving the analysis of fly population growth are powerful analytical tools for describing the long-term effects of ecological and behavioural patterns that are important for population dynamics, which are especially relevant for the demographic interpretation of species of medical-veterinary and forensic importance [25].The theory of population dynamics of single species has been applied extensively over the last 20 years to study both introduced and native blow fly species, in order to better understand aspects of the population biology of each species [25,26]. These studies have revealed important differences in the dynamics of population equilibrium Citation: Gião JZ, Reigada C, Moretti TC, Godoy WAC (2017) Effect of Psychoactive Drugs on Demographic Parameters of the Blow Fly Chrysomya albiceps (Wiedemann) (Diptera: Calliphoridae). J Forensic Res 8: 400.

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“…15 La obesidad es de origen multifactorial y correlaciona genes y estilos de vida. 16,17 Algunos factores, como el mayor consumo de alimentos procesados y bebidas azucaradas junto con una vida sedentaria, colaborarían en el incremento observado. 18 En un reciente estudio poblacional europeo constituido por 3000 niños, desde el nacimiento hasta los 5 años, se evaluó la asociación entre la susceptibilidad genética y la obesidad.…”

Section: Epidemiologíaunclassified

El niño obeso en la Unidad de Cuidados Intensivos. Puesta al día

F.¹,

L.²,

et al. 2016

Arch Argent Pediat

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Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

Cited by 363 publications

References 73 publications

When is incomplete epigenetic resetting in germ cells favoured by natural selection?

When is incomplete epigenetic resetting in germ cells favoured by natural selection?

Effect of Psychoactive Drugs on Demographic Parameters of the Blow Fly Chrysomya albiceps (Wiedemann) (Diptera: Calliphoridae)

El niño obeso en la Unidad de Cuidados Intensivos. Puesta al día

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