Paternal insulin resistance and fetal growth: problem for the ’fetal insulin' and the ’fetal origins' hypotheses

Available, Not Available Not

doi:10.1007/s001250100622

Cited by 15 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both showed the expected positive associations of maternal insulin resistance and offspring birthweight [30,31]. Paternal insulin resistance was unrelated to offspring birthweight in one study [30] and positively related in the other [31]. In Mysore parent and offspring birthweights were correlated [32] and if the inverse associations between parental birthweight and offspring metabolic syndrome in our study were genetic in origin, we would expect to see similar inverse associations between offspring birthweight and parental outcomes.…”

Section: Discussionsupporting

confidence: 53%

“…Studies in western populations [5-8, 12-18] and in India [30,31] have examined parental outcomes in relation to offspring birthweight. The western studies showed inverse relationships between offspring birthweight and paternal and maternal insulin resistance measured in middle-to-old age [8,13].…”

Section: Discussionmentioning

confidence: 99%

“…The Indian studies had shorter follow-up times than ours, the parents were younger and the offspring were children. Both showed the expected positive associations of maternal insulin resistance and offspring birthweight [30,31]. Paternal insulin resistance was unrelated to offspring birthweight in one study [30] and positively related in the other [31].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Relationships of maternal and paternal birthweights to features of the metabolic syndrome in adult offspring: an inter-generational study in South India

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis The association between lower birthweight and metabolic syndrome may result from fetal undernutrition (fetal programming hypothesis) and/or genes causing both low birthweight and insulin resistance (fetal insulin hypothesis). We studied associations between the birthweight of parents and metabolic syndrome in the offspring. Methods We identified men and women (aged 35-68 years), who had been born in Holdsworth Memorial Hospital, Mysore, India. We also identified the offspring (20-46 years) of these men and women. In total, 283 offspring of 193 mothers and 223 offspring of 144 fathers were studied. Investigations included anthropometry, oral glucose tolerance, plasma insulin and lipid concentrations and blood pressure. The metabolic syndrome was defined using WHO criteria.Results Among the offspring, lower birthweight was associated with an increased risk of glucose intolerance (impaired glucose tolerance, impaired fasting glucose or type 2 diabetes) and higher cholesterol and triacylglycerol concentrations (p<0.05 for all adjusted for sex and age). Most outcomes in the offspring, including most individual components of the metabolic syndrome, were unrelated to parental birthweight. However, both maternal and paternal birthweight were inversely related to offspring metabolic syndrome (odds ratio [OR] 0.36 [95% CI: 0.13-1.01] per kg, p=0.053 for mother-offspring pairs; OR 0.26 [0.07-0.93], p=0.04 for father-offspring pairs, adjusted for offspring age, sex, BMI and socioeconomic status). Maternal birthweight was inversely related to offspring systolic blood pressure (β=−2.5 mmHg [−5.00 to 0.03] per kg maternal birthweight; p=0.052). Conclusions/interpretation Factors in both parents may influence the risk of metabolic syndrome in their offspring. There are several possible explanations, but the findings are consistent with the fetal insulin (genetic) hypothesis.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationships of maternal and paternal birthweights to features of the metabolic syndrome in adult offspring: an inter-generational study in South India

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Fetal insulin hypothesis also predicted a low birth weight in children of diabetic fathers, this was first demonstrated in Pima Indians [50]. However, a direct relationship between paternal insulin resistance and offspring birth weight has also been demonstrated [51]. A number of common polymorphisms associated with diabetes have been shown to predict low birth weight, supporting genetic contribution to low birth weight and diabetes connection.…”

Section: Mechanisms Of Fetal Programming: Epigenetics and Geneticsmentioning

confidence: 94%

Maternal nutrition, intrauterine programming and consequential risks in the offspring

Yajnik¹,

Deshmukh²

2008

Rev Endocr Metab Disord

175

121

View full text Add to dashboard Cite

It is traditionally believed that genetic susceptibility and adult faulty lifestyle lead to type 2 diabetes, a chronic non-communicable disease. The "Developmental Origins of Health and Disease" (DOHaD) model proposes that the susceptibility to type 2 diabetes originates in the intrauterine life by environmental fetal programming, further exaggerated by rapid childhood growth, i.e. a biphasic nutritional insult. Both fetal under nutrition (sometimes manifested as low birth weight) and over nutrition (the baby of a diabetic mother) increase the risk of future diabetes. The common characteristic of these two types of babies is their high adiposity. An imbalance in nutrition seems to play an important role, and micronutrients seem particularly important. Normal to high maternal folate status coupled with low vitamin B(12) status predicted higher adiposity and insulin resistance in Indian babies. Thus, 1-C (methyl) metabolism seems to play a key role in fetal programming. DOHaD represents a paradigm shift in the model for prevention of the chronic non-communicable diseases.

show abstract

References

2005

Cardiovascular Disease

View full text Add to dashboard Cite

Paternal insulin resistance and fetal growth: problem for the ’fetal insulin' and the ’fetal origins' hypotheses

Cited by 15 publications

References 7 publications

Relationships of maternal and paternal birthweights to features of the metabolic syndrome in adult offspring: an inter-generational study in South India

Relationships of maternal and paternal birthweights to features of the metabolic syndrome in adult offspring: an inter-generational study in South India

Maternal nutrition, intrauterine programming and consequential risks in the offspring

References

Contact Info

Product

Resources

About