Paternal programming of fetoplacental and offspring metabolic disorders

Capobianco, Evangelina; Pirrone, Irune

doi:10.1016/j.placenta.2023.06.009

Placenta

2023

DOI: 10.1016/j.placenta.2023.06.009

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Paternal programming of fetoplacental and offspring metabolic disorders

Evangelina Capobianco,

Irune Pirrone

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Cited by 4 publications

References 92 publications

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Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model

Bozec,

Rousseau-Ralliard,

Jouneau

et al. 2024

Environmental Research

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Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model

Bozec,

Rousseau-Ralliard,

Jouneau

et al. 2024

Environmental Research

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A systematic review exploring evidence for adolescent understanding of concepts related to the developmental origins of health and disease

Tohi,

Tu’akoi,

Vickers

2023

J Dev Orig Health Dis

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The developmental origins of health and disease (DOHaD) framework has highlighted the importance of the early life period on disease risk in later life with impacts that can span generations. A primary focus to date has been around maternal health and the ‘First Thousand Days’ as a key developmental window whereby an adverse environment can have lasting impacts on both mother and offspring. More recently, the impact of paternal health has gathered increasing traction as a key window for early life developmental programming. However, to date, adolescents, the next generation of parents, have attracted less attention as a key DOHaD window although many behavioural traits become entrained during adolescence and track into adulthood. This systematic review examined literature focused on identifying adolescent understanding of DOHaD concepts. Consistent across the eligible articles was that overall understanding of DOHaD-related concepts in adolescents was low. Three key themes emerged: 1. Individual-level awareness of DOHaD concepts (cognitive engagement and action of the adolescents themselves); 2. Interpersonal communication and social awareness of DOHaD concepts (cognitive engagement and communication of the DOHaD concepts to family and wider community); and 3. Health literacy and the promotion of adolescence as a key DOHaD life stage. These findings highlight the need to develop strategic approaches to increase DOHaD awareness that are not only appealing to adolescents but can also support sustained changes in health behaviour. Investment in today’s adolescents has the potential to act as a NCD ‘circuit breaker’ and thus will yield significant dividends for future generations.

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Paternal obesity decreases infant MSC mitochondrial functional capacity

Jevtovic,

Claiborne,

Biagioni

et al. 2024

American Journal of Physiology-Endocrinology and Metabolism

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Besides the well-recognized influence of maternal health on fetal in utero development, recent epidemiological studies appoint paternal pre-conception metabolic health as a significant factor in shaping fetal metabolic programming and subsequently offspring metabolic health; however, mechanisms behind these adaptations remain confined to animal models. To elucidate the effects of paternal obesity (P-OB) on infant metabolism in humans, we examined mesenchymal stem cells (MSCs) which give rise to infant tissue, remain involved in mature tissue maintenance, and resemble the phenotype of the offspring donor. Here, we assessed mitochondrial functional capacity, content, and insulin action in MSC from infants of fathers with overweight (BMI 25-30kg/m2) (P-OW) or obesity (BMI≥30kg/m2) (P-OB), while controlling for maternal intrauterine environment. Compared to P-OW, infant MSCs in the P-OB group had lower intact cell respiration, OXPHOS, and electron transport system capacity, independent of any changes in mitochondrial content. Furthermore, glucose handling, insulin action, and lipid content and oxidation were similar between groups. Importantly, infants in the P-OB group had a greater weight-to-length ratio, which could be in part due to changes in MSC metabolic functioning which precedes and therefore influences infant growth trajectories. These data suggest that P-OB negatively influences infant MSC mitochondria.

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Paternal programming of fetoplacental and offspring metabolic disorders

Cited by 4 publications

References 92 publications

Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model

Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model

A systematic review exploring evidence for adolescent understanding of concepts related to the developmental origins of health and disease

Paternal obesity decreases infant MSC mitochondrial functional capacity

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