Paternal race is a risk factor for preterm birth

Palomar, Lisanne; DeFranco, Emily; Lee, Kirstin A.; Allsworth, Jenifer E.; Muglia, Louis J.

doi:10.1016/j.ajog.2007.03.035

Cited by 62 publications

(42 citation statements)

References 38 publications

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“…These findings suggest that other critical paternal sociocultural, sociodemographic factors may be at play that could not be assessed because of the limitations of the data set used in this analysis. Previous studies have indicated that an association exists between paternal race/ethnicity (Krishnakumar et al, 2011;Palomar, DeFranco, Lee, Allsworth, & Muglia, 2007), education (Blumenshine, Egerter, Libet, & Braveman, 2011;Bray, Gunnell, & Smith, 2006;Chen et al, 2008;Kiernan, 1997;Saikh et al, 2011), support and involvement (Alio et al, 2011;Alio, Kornosky, Mbah, Marty, & Salihu, 2010;Ghosh, Wilhelm, Dunkel-Schetter, Lombardi, & Ritz, 2010), and alcohol, tobacco, and drug use (Chen et al, 2008;Little & Sing, 1986;Vine, 1996) and adverse feto-infant outcomes. Consequently, it may be beneficial for interconception care, which incorporates prenatal care, to include both mothers and fathers to prevent or minimize health problems for mother and child (Johnson et al, 2006;Mercer et al, 1999;Surkan, Stephansson, Dickman, & Cnattingius, 2004).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Paternal Age on Fetal Birth Outcomes

et al. 2012

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Research investigating the role of paternal age in adverse birth outcomes is limited. This population-based retrospective cohort study used the Missouri maternally linked data set from 1989 to 2005 to assess whether paternal age affects fetal birth outcomes: low birth weight (LBW), preterm birth (PTB), stillbirth, and small size for gestational age (SGA). We examined these outcomes among infants across seven paternal age-groups (<20, 20-24, 25-29, 30-34, 35-39, 40-45, and >45 years) using the generalized estimating equation framework. Compared with infants born to younger fathers (25-29 years), infants born to fathers aged 40 to 45 years had a 24% increased risk of stillbirth but a reduced risk of SGA. A 48% increased risk of late stillbirth was observed in infants born to advanced paternal age (>45 years). Moreover, advanced paternal age (>45 years) was observed to result in a 19%, 13%, and 29% greater risk for LBW, PTB, and VPTB (very preterm birth) infants, respectively. Infants born to fathers aged 30 to 39 years had a lower risk of LBW, PTB, and SGA, whereas those born to fathers aged 24 years or younger had an elevated likelihood of experiencing these same adverse outcomes. These findings demonstrate that paternal age influences birth outcomes and warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

The Effect of Paternal Age on Fetal Birth Outcomes

et al. 2012

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“…Since pregnancies in which either the mother [4,7] or father [19,20] is Black are at increased risk for preterm delivery, we tested for evidence of genetic heterogeneity between these two groups. Segregation analyses of infant's gestational age and mother's average gestational age over all her children also were performed in Black and White subgroups.…”

Section: Heterogeneity Between Blacks and Whitesmentioning

confidence: 99%

“…Paternal race also has been associated with preterm birth risk. Previous studies observed that preterm birth rates are highest when both parents are Black and remain higher when one parent is Black, whether that parent is the mother or father [19,20] , suggesting that fetal race also influences birth timing. However, father's family history of preterm birth has been shown to have only a weak association with risk.…”

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confidence: 99%

“…We also tested parent of origin models for infant's gestational age to examine whether mother's genotype is the sole determinant of variation in this trait. Additionally, as pregnancies in which either the mother [4,7] or father [19,20] is Black are at increased risk for preterm delivery, we performed segregation analysis for each phenotype in the total sample, as well as stratified by Black and White race, to test for heterogeneity between these two groups.…”

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confidence: 99%

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Mother’s Genome or Maternally-Inherited Genes Acting in the Fetus Influence Gestational Age in Familial Preterm Birth

Plunkett

Feitosa²,

Trusgnich

et al. 2009

Hum Hered

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Objective: While multiple lines of evidence suggest the importance of genetic contributors to risk of preterm birth, the nature of the genetic component has not been identified. We perform segregation analyses to identify the best fitting genetic model for gestational age, a quantitative proxy for preterm birth. Methods: Because either mother or infant can be considered the proband from a preterm delivery and there is evidence to suggest that genetic factors in either one or both may influence the trait, we performed segregation analysis for gestational age either attributed to the infant (infant’s gestational age), or the mother (by averaging the gestational ages at which her children were delivered), using 96 multiplex preterm families. Results: These data lend further support to a genetic component contributing to birth timing since sporadic (i.e. no familial resemblance) and nontransmission (i.e. environmental factors alone contribute to gestational age) models are strongly rejected. Analyses of gestational age attributed to the infant support a model in which mother’s genome and/or maternally-inherited genes acting in the fetus are largely responsible for birth timing, with a smaller contribution from the paternally-inherited alleles in the fetal genome. Conclusion: Our findings suggest that genetic influences on birth timing are important and likely complex.

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“…Genetic predisposition for PTB [4][5][6] has been hypothesized based upon: 1) demonstration of familial aggregation; [7][8][9][10][11] 2) measures of heritability; [11][12][13][14][15] 3) identification of diseasesusceptibility genes; and 4) racial disparity in preterm birth rate [16][17][18][19] that may be related to frequency differences in risk predisposing alleles. [20][21][22][23][24] Familial aggregation, defined as the co-occurrence of a trait in members of a family that can not be readily accounted for by chance, has been demonstrated for PTB.…”

Section: Introductionmentioning

confidence: 99%

14: Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

Romero¹,

Velez²,

Mazaki‐Tovi³

et al. 2009

American Journal of Obstetrics and Gynecology

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Objective-To determine whether maternal/fetal SNPs in candidate genes are associated with spontaneous preterm labor/delivery. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptStudy Design-A genetic association study was conducted in 223 mothers and 179 fetuses [preterm labor with intact membranes who delivered <37 weeks (PTB)], and 599 mothers and 628 fetuses (normal pregnancy): 190 candidate genes and 775 SNPs were studied. Single locus/ haplotype association analyses were performed; FDR was used to correct for multiple testing (q*=0.15)]. Results-1)The strongest single locus associations with PTB were IL6R (fetus: p=0.000148) and TIMP2 (mother: p=0.000197), remaining significant after correction for multiple comparisons; 2) Global haplotype analysis indicated an association between a fetal DNA variant in IGF2 and maternal COL4A3 (global p=0.004 and 0.007, respectively).Conclusion-A SNP involved in controlling fetal inflammation (IL6R) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix biology approximately doubled the risk of PTB.

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Paternal race is a risk factor for preterm birth

Cited by 62 publications

References 38 publications

The Effect of Paternal Age on Fetal Birth Outcomes

The Effect of Paternal Age on Fetal Birth Outcomes

Mother’s Genome or Maternally-Inherited Genes Acting in the Fetus Influence Gestational Age in Familial Preterm Birth

14: Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

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