Paternity in a patient with testicular seminoma and contralateral testicular intraepithelial neoplasia

Abstract

A 32-year-old patient with unilateral beta hCG-positive seminoma and contralateral testicular intraepithelial neoplasia (TIN; so-called carcinoma-in-situ) with no metastases (clinical stage I) received one course of adjuvant carboplatin therapy. He refused further treatment of TIN in his remaining testis. His wife became pregnant by him 4 months later and delivered a healthy child at term. This case shows that patients with TIN in their remaining solitary testis are not necessarily infertile, and testes afflicted with TIN must also contain tubules that retain normal spermatogenic potential. Surveillance may be an treatment option for patients with TIN in their remaining testis in cases where there is a strong desire for paternity.

Testis sparing surgery for the treatment of a sequential bilateral testicular germ cell tumor

“…It is well known that fertility is usually much reduced in men with testicular cancer and patients having CIS are expected to have an even worse semen quality 13 . However, although unusual, paternity was reported in men with BTGCT and even in a man with seminoma and CIS in a solitary testis treated with partial orchiectomy 9,10,14 10 but the risk of relapse is minimal in the absence of CIS, as in our case.…”

Management of contralateral testicular intraepithelial neoplasia in patients with testicular germ-cell tumor

“…These conditions will probably be met in only a minority of patients. However, expectant management might be worthy of consideration, as even in this situation, paternity is not impossible [6].…”

Fatherhood in Testicular Cancer Patients with Carcinoma in situ in the Contralateral Testicle

“…The tubules harboring CIS are usually devoid of spermatogenesis and the neighboring tubules usually display severely impaired spermatogenesis [2, 3]. However, not all patients with contralateral CIS are necessarily infertile [4, 5]. In addition, newer techniques for cryopreservation [6]and assisted fertilization allow fatherhood even with highly oligospermic semen samples as demonstrated by our 3 case reports.…”