The path tracking controller can easily reduce the tracking error, but often exceed the limitations of vehicle stability. In this paper, an intelligent vehicle path tracking control strategy considering data-driven dynamic stable region constraints is proposed. Firstly, based on the two-degree-of-freedom (DOF) vehicle model and nonlinear tire model, the vehicle sideslip angle-sideslip angular velocity ([Formula: see text]) phase plane is established. Then, the stable region dataset is made considering the influence of vehicle speed, adhesion coefficient, and front wheel angle. To get the vehicle driving stable region, a back propagation neural network (BP-NN) regression model is trained offline. Subsequently, a path tracking control strategy based on adaptive-model predictive control (MPC) is designed, which considers the vehicle dynamic stable region constraints with the BP-NN predicting online. Finally, model-in-the-loop (MIL) and driving simulator is designed to test the control strategy, which indicates that it has a better performance compared with the linear quadratic regulator (LQR) path tracking controller.