Patho-Pharmacological Research of Anti-allergic Natural Products Targeting Antihistamine-Sensitive and -Insensitive Allergic Mechanisms

Fukui, Hirokazu; Mizuguchi, Hiroyuki; Kitamura, Yoshiaki; Takeda, Noriaki

doi:10.1007/7854_2021_255

Cited by 2 publications

(1 citation statement)

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“…Stamen is the most valuable part of sacred lotus, and is employed in several traditional medicines or herbal drugs for relaxation and health benefits, such as boosting the immune system and improving blood circulation [ 4 , 10 , 11 ]. According to the preparation of various traditional medicines; for example, Chinese traditional medicines, Kampo medicines (the traditional Japanese herbal medicines), and Thai traditional medicines, these raw plant materials are commonly used in the form of an extract [ 12 , 13 , 14 , 15 ], following the traditional knowledge that the extract, which consists of major bioactive compounds, will provided synergistic effects for the health benefits of mankind. Nowadays, the number of research studies on the potential pharmacological activities of N. nucifera are considerably increased [ 7 , 8 , 9 , 10 , 11 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids from Sacred Lotus Stamen Extract Slows Chronological Aging in Yeast Model by Reducing Oxidative Stress and Maintaining Cellular Metabolism

Drouet

Hano

2022

Cells

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Nelumbo nucifera is one of the most valuable medicinal species of the Nelumbonaceae family that has been consumed since the ancient historic period. Its stamen is an indispensable ingredient for many recipes of traditional medicines, and has been proved as a rich source of flavonoids that may provide an antiaging action for pharmaceutical or medicinal applications. However, there is no intense study on antiaging potential and molecular mechanisms. This present study was designed to fill in this important research gap by: (1) investigating the effects of sacred lotus stamen extract (LSE) on yeast lifespan extension; and (2) determining their effects on oxidative stress and metabolism to understand the potential antiaging action of its flavonoids. A validated ultrasound-assisted extraction method was also employed in this current work. The results confirmed that LSE is rich in flavonoids, and myricetin-3-O-glucose, quercetin-3-O-glucuronic acid, kaempferol-3-O-glucuronic acid, and isorhamnetin-3-O-glucose are the most abundant ones. In addition, LSE offers a high antioxidant capacity, as evidenced by different in vitro antioxidant assays. This present study also indicated that LSE delayed yeast (Saccharomyces cerevisiae, wild-type strain DBY746) chronological aging compared with untreated control yeast and a positive control (resveratrol) cells. Moreover, LSE acted on central metabolism, gene expressions (SIR2 and SOD2), and enzyme regulation (SIRT and SOD enzymatic activities). These findings are helpful to open the door for the pharmaceutical and medical sectors to employ this potential lotus raw material in their future pharmaceutical product development.

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