2012
DOI: 10.1155/2012/893876
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Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics

Abstract: Insulin resistance in skeletal muscle tissues and diabetes-related muscle weakness are serious pathophysiological problems of increasing medical importance. In order to determine global changes in the protein complement of contractile tissues due to diabetes mellitus, mass-spectrometry-based proteomics has been applied to the investigation of diabetic muscle. This review summarizes the findings from recent proteomic surveys of muscle preparations from patients and established animal models of type 2 diabetes. … Show more

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Cited by 18 publications
(11 citation statements)
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“…It will be of interest to investigate whether exercise can reverse this obesity-related metabolic syndrome and increase oxidative capacity to levels as normally seen in healthy lean muscle tissue. A large number of proteomic studies have studied the effects of type 2 diabetes and metabolic impairments on the muscle proteome 36 . Insulin-resistant human muscle was demonstrated to be associated with an oxidative-to-glycolytic shift.…”
Section: Resultsmentioning
confidence: 99%
“…It will be of interest to investigate whether exercise can reverse this obesity-related metabolic syndrome and increase oxidative capacity to levels as normally seen in healthy lean muscle tissue. A large number of proteomic studies have studied the effects of type 2 diabetes and metabolic impairments on the muscle proteome 36 . Insulin-resistant human muscle was demonstrated to be associated with an oxidative-to-glycolytic shift.…”
Section: Resultsmentioning
confidence: 99%
“…These findings are consistent with protein changes in glycolytic pathway proteins in other systems. For example, this glycolytic shift has been studied widely as a major contributor to insulin resistance and weakness using proteomics in skeletal muscle [ 32 , 56 58 ]. We also know that corneal edema is a common finding in diabetic patients [ 59 , 60 ], which is consistent with poor endothelial cell Na + /K + -ATPase pump and tight-junction barrier functions secondary to cell health and dropout [ 1 , 61 ].…”
Section: Discussionmentioning
confidence: 99%
“…Insulin resistance may be an important mechanism in the development of skeletal muscle weakness [25]. Exercise training aims to modify skeletal muscle function to enhance exercise capacity [26] and may confer an increase in physical activity. Also the level of physical activity is most important factor in determining self -reported general health and health related quality of life in people with COPD [27,28].…”
Section: Discussionmentioning
confidence: 99%