Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray

Abstract

Aim: To investigate the pathobiological features of intestinal and diffuse-type gastric carcinomas in the Japanese population. Methods: The expression of fragile histine triad (FHIT), phosphatase and tensin homology deleted from human chromosome 10 (PTEN), caspase-3, Ki-67, mutant p53, matrix metalloproteinase (MMP)-2, MMP-9, and extracellular matrix metalloproteinase inducer (EMMPRIN) on tissue microarrays of gastric carcinomas by immunostaining was examined in comparison with the clinicopathological characteristics between intestinal and diffuse-type cases. Results: Intestinal-type carcinoma frequently occurred in old men, whereas the diffuse type comparatively occurred more in young women (p,0.05). The diffuse-type carcinoma was more inclined to invasion into muscularis propria, lymphatic invasion and lymph node metastasis, and belonged to higher International Union against Cancer (UICC) staging (p,0.05) compared with intestinal-type counterparts. Expression of FHIT, PTEN, Ki-67, caspase-3, mutant p53 and EMPPRIN was higher in intestinal-type carcinomas than in diffuse-type carcinomas (p,0.05). Kaplan-Meier analysis indicated that patients with intestinal-type carcinomas had a higher cumulative survival rate (p,0.05). Conclusion: Intestinal-type gastric carcinomas with a more favourable prognosis frequently show high levels of proliferation and apoptosis, and always accompany strong expression of FHIT, PTEN and mutant p53 and EMMPRIN. EMMPRIN expression might underlie the molecular basis of liver metastasis and higher proliferation of intestinal-type gastric carcinomas in Japan. Lauren's classification thus proved pathologically relevant for the clinical treatment of gastric carcinomas.

Pathobiological Characteristics of Intestinal and Diffuse-Type of Gastric Carcinoma-Retrospective Study of Gastric Cancers

“…This shows that Younger patients had a higher incidence of lymph node metastasis of gastric cancer of diffuse type, but not for the intestinal type. Results of the present study was in accordance with other studies, [6,10,11] gastric cancer was most common in 5 th to 6 th decade. Male: female ratio was 2:1.…”

“…Lauren's classification thus proved pathologically relevant for the clinical treatment of gastric carcinomas. [6] The best predictor of prognosis is the pathologic stage, which includes the depth of invasion, the extent of nodal involvement, and the presence or absence of distant metastasis. [2] Younger patients had a higher incidence of lymph node metastasis of gastric cancer of diffuse type, but not for the intestinal type.…”

Malignant Gastrointestinal Tumours in South Western Nigeria: A Histopathologic Analysis of 713 Cases

“…It is associated with high level of proliferation and apoptosis as well as expression of some tumour suppressor genes such as FHIT, PTEN, p53 and MMP. 23 Other types of malignancies in the stomach include lymphomas either as extra nodal primary non-Hodgkin's lymphoma or MALToma. Gastric mesenchymal tumours accounted for 5.8% in this series similar to report in the literature and majority have light microscopic features consistent with gastrointestinal stromal tumour (GIST).…”

Pathobiological Characteristics of Intestinal and Diffuse-Type of Gastric Carcinoma-Retrospective Study of Gastric Cancers

“…Younger patients (<60 years) had higher stage of nodal metastasis in diffuse type. Ming SC et al [10] >50 104(61%) 67(39%) 2:1 114(67%) 57(33%) -Zheng H et al [6] 60-70 222(70%) 94(30%) 2:1 ---Graziosi L et al [11] 50-60 68(60%) 45(40%) 2:1 65(57%) 45(39%) 4(4%)…”