2013
DOI: 10.1007/978-1-4614-5438-0
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Pathobiology of Cancer Regimen-Related Toxicities

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Cited by 6 publications
(2 citation statements)
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“…Data outlining molecular mechanisms by which treatment-related fibrosis develops has largely been captured from animal models that accurately replicate chemotherapy or radiotherapy regimens routinely used in patients (Sonis and Keefe, 2013). Immediately following insult due to chemotherapy and radiation, there is a large cellular response that involves cell type specific programs occurring in three general phases ( Figure 1 ).…”
Section: Mechanisms Of Fibrosismentioning
confidence: 99%
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“…Data outlining molecular mechanisms by which treatment-related fibrosis develops has largely been captured from animal models that accurately replicate chemotherapy or radiotherapy regimens routinely used in patients (Sonis and Keefe, 2013). Immediately following insult due to chemotherapy and radiation, there is a large cellular response that involves cell type specific programs occurring in three general phases ( Figure 1 ).…”
Section: Mechanisms Of Fibrosismentioning
confidence: 99%
“…These regimen-related toxicities are not only associated with poor health outcomes, but they often become dose-limiting for patients and impair patients’ quality of life (QoL) and recovery in both the short and the long term (Elting et al, 2008). Hematological disorders such as anemia, thrombocytopenia, and neutropenia are among the most common complications associated with radiation and chemotherapy; however, cancer patients are also at risk for a wide range of non-hematological toxicities (Sonis and Keefe, 2013). The overall incidence of some form of cancer treatment-related toxicity is almost 100% and can occur both during cancer treatment (acute toxicities), or will develop well after the completion of treatment (≥100 days, late toxicities).…”
Section: Introductionmentioning
confidence: 99%