Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis

Riviere, George R.; Weisz, K S; Simonson, Lloyd G.; Lukehart, Sheila A.

doi:10.1128/iai.59.8.2653-2657.1991

Cited by 68 publications

(47 citation statements)

References 18 publications

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“…43,44 Culture studies identified P. intermedia, and Treponema, Selenomonas and Fusobacterium species, which were considered "constant flora" in NPD lesions. 45 The role of spirochetes was confirmed by immuno assays 46,47 and PCR targeting 16s rRNA. 48 Recent studies by phylogenetic analysis also…”

Section: Clinical Presentationmentioning

confidence: 96%

Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo‐periodontal lesions

Herrera

Retamal‐Valdes

Alonso

et al. 2018

J Clinic Periodontology

106

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Objective To critically evaluate the existing literature on acute lesions occurring in the periodontium (periodontal abscesses [PA], necrotizing periodontal diseases [NPD], and endo‐periodontal lesions [EPL]) to determine the weight of evidence for the existence of specific clinical conditions that may be grouped together according to common features. The ultimate goal is to support an objective classification system. Importance Although PA, NPD, and EPL occur with relatively low frequency, these lesions are of clinical relevance, because they require immediate management and might severely compromise the prognosis of the tooth. Findings In general, the evidence available to define these three conditions was considered limited. PA and EPL are normally associated with deep periodontal pockets, bleeding on probing, suppuration, and almost invariably, with pain. EPL are also associated with endodontic pathology. NPDs have three typical features: pain, bleeding, and ulceration of the gingival interdental papilla. The available data suggested that the prognosis of PA and EPL are worse in periodontitis than in nonperiodontitis patients. Lesions associated with root damage, such as fractures and perforations, had the worst prognosis. NPD progression, extent and severity mainly depended on host‐related factors predisposing to these diseases. Conclusions PA should be classified according to the etiological factors involved, with the most frequent being those occurring in pre‐existing periodontal pockets. NPD are clearly associated with the host immune response, which should be considered in the classification system for these lesions. EPLs should be classified according to signs and symptoms that have direct impact on their prognosis and treatment, such as presence or absence of fractures and perforations, and presence or absence of periodontitis.

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Section: Clinical Presentationmentioning

confidence: 96%

Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo‐periodontal lesions

Herrera

Retamal‐Valdes

Alonso

et al. 2018

J Clinic Periodontology

106

View full text Add to dashboard Cite

show abstract

“…T. denticola cells were identified by their reactivity with specific immunogold colloidal reagents (black dots). Bar 1 lm. immune responses to treponemal antigens, which is evidence that spirochetes or their products interact sufficiently with host cells to provoke systemic reactions (70,131,163). Invasive treponemes include a variety of species.…”

Section: T Denticolamentioning

confidence: 99%

Spirochetes at the forefront of periodontal infections

Ellen¹,

Galimanas²

2005

Periodontology 2000

154

146

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“…Electron-microscopic studies have described spirochaetes invading gingival connective tissues of acute necrotizing ulcerative gingivitis lesions (84). Recently, pathogen-related oral spirochetes have been detected in plaque samples from acute necrotizing ulcerative gingivitis patients and in tissue biopsies (134). Chung et al (32) and Loesche et al (87) identified P. intermedia as a putative pathogen in acute necrotizing ulcerative gingivitis lesions of young adults in the United States.…”

Section: Acute Necrotizing Ulcerative Gingivitismentioning

confidence: 99%