Pathogen vacuole membrane contact sites – close encounters of the fifth kind

Vormittag, Simone; Ende, Rachel; Derré, Isabelle; Hilbi, Hubert

doi:10.1093/femsml/uqad018

Cited by 11 publications

(2 citation statements)

References 262 publications

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“…Bacterial effectors localize to various host cell organelles, using molecular mimicry to manipulate host metabolism and promote bacterial survival. Recent studies have unveiled that, in addition to adopting eukaryotic catalytic and receptor domains as a form of molecular mimicry, bacterial effector proteins can also contain features of eukaryotic tether proteins and establish inter-organelle contact sites between the host ER and BCV membranes (Murray et al, 2017; Vormittag et al, 2023). Remarkably, although several bacterial effector proteins localize to host cell organelles outside the context of the BCV, none have been identified to mediate inter-organelle contact sites.…”

Section: Introductionmentioning

confidence: 99%

The novel bacterial effector proteinCbEPF1 mediates ER-LD membrane contacts to regulate host lipid droplet metabolism

Angara,

Sadi,

Gilk

2023

Preprint

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Effective intracellular communication between cellular organelles is pivotal for maintaining cellular homeostasis. Tether proteins, which are responsible for establishing membrane contact sites between cell organelles, enable direct communication between organelles and ultimately influence organelle function and host cell homeostasis. While recent research has identified tether proteins in several bacterial pathogens, their functions have predominantly been associated with mediating inter-organelle communication specifically between the bacteria containing vacuole (BCV) and the host endoplasmic reticulum (ER). However, this study reveals a novel bacterial effector protein,CbEPF1, which acts as a molecular tether beyond the confines of the BCV and facilitates interactions between host cell organelles.Coxiella burnetii, an obligate intracellular bacterial pathogen, encodes the FFAT motif-containing proteinCbEPF1 which localizes to host lipid droplets (LDs).CbEPF1 establishes inter-organelle contact sites between host LDs and the ER through its interactions with VAP family proteins. Intriguingly,CbEPF1 modulates growth of host LDs in a FFAT motif-dependent manner. These findings highlight the potential for bacterial effector proteins to impact host cellular homeostasis by manipulating inter-organelle communication beyond conventional BCVs.

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Section: Introductionmentioning

confidence: 99%

The novel bacterial effector proteinCbEPF1 mediates ER-LD membrane contacts to regulate host lipid droplet metabolism

Angara,

Sadi,

Gilk

2023

Preprint

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“…An emerging platform for direct communication is membrane contact sites (MCSs), a term used to define regions of membrane apposition between organelles in a 10–30 nm range. MCSs form between several pathogens and host organelles ( 1 , 2 ). How MCSs are formed, the extent to which they mediate host-pathogen communication, and the role they play during infection remain open questions.…”

Section: Introductionmentioning

confidence: 99%

Contact sites between host organelles and pathogens: boon or bane?

Mehra,

Pernas

2023

mSphere

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A microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondria and the human parasite Toxoplasma gondii . We discuss open questions regarding their function during infection as well as those formed between the host endoplasmic reticulum and Toxoplasma .

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Apicomplexan Espionage: Orchestrated Miscommunication at the Host–Parasite Interface

Mohan,

Vinjamuri,

Sahoo

et al. 2024

ACS Infect. Dis.

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Intracellular parasites, including Toxoplasma and Plasmodium, are entirely reliant on the active scavenging of host-derived nutrients to fuel their replicative cycle, as they are confined within a specialized membranebound compartment, the parasitophorous vacuole (PV). Initial observations, based on the proximity of host vesicles to the parasitophorous vacuole membrane (PVM), suggested that parasites utilize host vesicles to obtain essential nutrients. However, mounting evidence has now unequivocally demonstrated that intracellular pathogens establish membrane contacts with host organelles, establishing control over host cellular machinery. These intimate interactions enable the parasites to gain unimpeded access to cytosolic resources critical for development while evading host immune responses. This review consolidates the latest advancements in understanding the molecular machinery driving these transkingdom contacts and their functional roles. Further investigation into these processes promises to revolutionize our understanding of organelle communication, with profound implications for identifying new therapeutic targets and strategies.

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Pathogen vacuole membrane contact sites – close encounters of the fifth kind

Cited by 11 publications

References 262 publications

The novel bacterial effector proteinCbEPF1 mediates ER-LD membrane contacts to regulate host lipid droplet metabolism

The novel bacterial effector proteinCbEPF1 mediates ER-LD membrane contacts to regulate host lipid droplet metabolism

Contact sites between host organelles and pathogens: boon or bane?

Apicomplexan Espionage: Orchestrated Miscommunication at the Host–Parasite Interface

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