2012
DOI: 10.1159/000338947
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Pathogenesis and Bisphosphonate Treatment of Skeletal Events and Bone Pain in Metastatic Cancer: Focus on Ibandronate

Abstract: Bone metastases are the most common cause of pain in patients with advanced cancer, and are associated with progressive skeletal destruction, spinal problems, and hypercalcaemia. Radiotherapy, analgesia, and surgery are the accepted treatment options for chronic malignant bone pain, with a stepped approach being generally recommended. In the past decade, the bisphosphonates, which reduce bone turnover, increase bone mass, and decrease the risk of fracture, have become established as an effective treatment in p… Show more

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Cited by 9 publications
(6 citation statements)
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“…Although there are likely several sources of pain in OA, it seems logical that antiresorptives should reduce bone pain caused by elevated levels of bone remodeling, since this is the case in the high bone turnover states of Paget's disease, 74 osteogenesis imperfecta, 75 and cancerinduced bone pain. 76 The results of the trial by Laslett et al 73 suggest that this is a possibility in OA.…”
Section: Directing Treatments For Osteoarthritis To the Subchondral Bonementioning
confidence: 99%
“…Although there are likely several sources of pain in OA, it seems logical that antiresorptives should reduce bone pain caused by elevated levels of bone remodeling, since this is the case in the high bone turnover states of Paget's disease, 74 osteogenesis imperfecta, 75 and cancerinduced bone pain. 76 The results of the trial by Laslett et al 73 suggest that this is a possibility in OA.…”
Section: Directing Treatments For Osteoarthritis To the Subchondral Bonementioning
confidence: 99%
“…Sử dụng trong điều trị và ngăn chặn loãng xương ở phụ nữ mãn kinh. Ngoài ra ibandronic acid có hiệu quả ngăn ngừa gãy xương di căn trong đa u tủy xương, ung thư vú và một số ung thư khác [10,11]. Sulfasalazine Là một sulfonamid kháng khuẩn, được chấp thuận là thuốc tại Hoa Kỳ năm 1950.…”
Section: Kết Quả Và Bàn Luậnunclassified
“…Ngoài ra sulfasalazine cũng được chỉ định trong viêm khớp dạng thấp và một số trường khớp khác như viêm khớp vẩy nến. Nghiên cứu tại đại học Newcastle phát hiện thuốc còn có tác dụng hỗ trợ điều trị xơ gan [11]. Hiện sử dụng nhiều trong điều trị mày đay tự phát không đáp ứng thuốc kháng histamin [12,13].…”
Section: Kết Quả Và Bàn Luậnunclassified
“…Ibandronic acid (C 9 H 23 NO 7 P 2 ) is also a second generation of BP medication that is applied in the prohibition and cures the osteoporosis and metastasis associated skeletal fractures with cancer disease. It might also be used to cure the increasing the blood calcium levels in hypercalcemia (Bauss and Schimmer, 2006; Sittig, 2012). Neridronic acid (C 6 H 17 NO 7 P 2 ) is in a class of bisphosphonates medications which is used to treat imperfect osteogenesis and Paget’s disease of bone (Gatti et al , 2009; Varenna et al , 2013).…”
Section: Introductionmentioning
confidence: 99%