Pathogenesis and current therapies for non-infectious uveitis

Wu, Xue Shen; Tao, Mengying; Zhu, Ling; Zhang, Ting; Zhang, Ming

doi:10.1007/s10238-022-00954-6

Cited by 16 publications

(3 citation statements)

References 211 publications

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“…Etanercept (Enbrel; Amgen, Inc. Thousand Oaks, CA, USA) is a soluble recombinant TNF receptor fusion protein, mainly composed of TNF-α receptor and IgG1 Fc [51], which was approved by the FDA in 1998 for the treatment of RA, AS, psoriatic arthritis(PsA) and so on. The main mechanism of action of this drug is to act as an anti-inflammatory by combining with TNF1 and TNF2 receptors thereby preventing the binding to TNF-α and thus providing an anti-inflammatory effect [43].…”

Section: Etanercept (Etn)mentioning

confidence: 99%

Progress in the Use of Glucocorticoids and Biological Agents in Non-Infectious Uveitis

Liu,

Zou,

Cheng

et al. 2024

JBM

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Section: Etanercept (Etn)mentioning

confidence: 99%

Progress in the Use of Glucocorticoids and Biological Agents in Non-Infectious Uveitis

Liu,

Zou,

Cheng

et al. 2024

JBM

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“…The role of immunological disorders in the pathogenesis of uveitis has been proven by numerous studies [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of formation and classification of secondary immunodeficiency states in uveitis

Panchenko,

Bezditko,

Honchar

et al. 2023

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Background. The role of immunological disorders in the pathogenesis of uveitis has been proven by numerous studies. However, there are different views on the timing and methods of immunocorrection. In our opinion, this issue should be solved on the basis of determining the mechanisms of the formation of immunodeficiency states in uveitis. The purpose of this work was to develop a classification of secondary immunodeficiency states in uveitis according to the mechanism of formation. Materials and Methods. The paper presents the results of the examination of 370 patients with uveitis (416 eyes; 179 were men, 191 were women, aged from 16 to 87 years; the duration of the disease ranged from 1 month to 32 years) who were treated in Kharkiv Regional Clinical Hospital, were under dispensary supervision at Kharkiv Regional Anti-Tuberculosis Dispensary and Kharkiv Regional Dispensary for Radiation Protection of the Population, or were examined, consulted and treated on an outpatient basis. The observation period was up to five years. Results. Based on the study of immunological changes in patients with uveitis, the dynamics of immunological disorders in relapses of the inflammatory process in the uveal tract, clinical and immunological features of various forms of uveitis, and the results of correction of immunological disorders in patients with uveitis, a classification of secondary immunodeficiency states in uveitis according to the mechanism of their formation was proposed. On its basis, the principles of correction of immunodeficiency states in patients with uveitis were developed. Keywords: infectious uveitis, noninfectious uveitis, cellular immunity, humoral immunity, correction principles, immunological disorders.

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“…These released cytokines further recruit leucocytes and neutrophils from the circulation and enhance inflammation, causing tissue damage (5)(6)(7). While the exact trigger and cause of the disease remain unknown, many studies based on different animal models showed that autoimmune responses to various ocular antigens triggered inflammation, as seen in non-infectious uveitis (8)(9)(10)(11). Some recent studies that were focused on the underlying mechanisms of uveitis, indicated that complement proteins could be involved in the pathogenesis of uveitis.…”

Section: Introductionmentioning

confidence: 99%

Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis

Kulshrestha,

Goel,

Murthy

et al. 2023

Front. Immunol.

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PurposeNon-infectious uveitis is a complex disease characterized by intraocular inflammation of the uveal area and the leading cause of vision impairment and blindness in young people globally. However, what triggers inflammation and contributes to its recurrence remains unclear. The complement system has been linked to various immunological and inflammatory conditions. In the present study, we have systematically evaluated the role of the alternative complement pathway in the pathogenesis of non-infectious uveitis.MethodologyQuantitative PCR was done in the peripheral leukocytes to study the expression of genes and regulatory miRNA in both anterior and posterior uveitis (n=28 in each category). Multiplex ELISA was performed to measure alternative pathway complement components, such as C3b, factor B, and CFH, and aqueous humor of infectious and non-infectious uveitis patients and non-inflammatory controls (n=10 each). Western blotting was done to validate the ELISA findings in a subset of patients and controls.ResultsDownregulation of C3 and CFH mRNA in the peripheral blood was shown by quantitative PCR in the group of anterior uveiits (AU), while the opposite result was found in the group of posterior uveitis (PU). ELISA levels of C3b and CFH proteins were significantly higher in aqueous humor of infectious and non-infectious uveitis (*p = 0.03 and **p = 0.0007 respectively) as compared to the control group. Western blotting further validated (VitH) the activation of the complement cascade in the aqueous (AH) and vitreous humor of patients with non-infectious uveitis, with an increased level of C3b (n=6) and CFH (n=4) in aqueous humor. C3b level was significantly increased while CFH was reduced relative to controls in the vitreous humor (VitH) of posterior uveitis patients compared to controls (n=27 in each category). A C3b to CFH ratio was computed to assess the regulation of complement activation and this index was several folds higher in both anterior and posterior uveitis (n=10 each). The expression of miRNA-hsa-miR-146a and miRNA-hsa-miR-155-5p that regulates CFH was downregulated and nicely correlated with the increased complement proteins in both anterior and posterior uveitis (n=10 each).ConclusionOur results demonstrate a clear role of CFH and the activation of the alternative complement pathway in the pathogenesis of non-infectious uveitis; however, its therapeutic potential warrants further investigations.

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Pathogenesis and current therapies for non-infectious uveitis

Cited by 16 publications

References 211 publications

Progress in the Use of Glucocorticoids and Biological Agents in Non-Infectious Uveitis

Progress in the Use of Glucocorticoids and Biological Agents in Non-Infectious Uveitis

Mechanisms of formation and classification of secondary immunodeficiency states in uveitis

Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis

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