Pathogenesis and Pathogenesis Related Treatment of Acne

Gollnick, Harald; Zouboulis, Christos C.; Akamatsu, Hirohiko; Kurokawa, Ichiro; Schulte, Anja

doi:10.1111/j.1346-8138.1991.tb03122.x

Cited by 81 publications

(68 citation statements)

References 47 publications

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“…19 Subsequent hyperkeratinisation of the hair follicle prevents normal shedding of the follicular keratinocytes, which then obstruct the follicle and form an inapparent microcomedo. 20 Lipids and cellular debris soon accumulate within the blocked follicle.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ah shi Point Acupuncture on Acne Vulgaris

2010

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Background Ah shi point acupuncture involves inserting needles at painful or pathological sites. Objective To evaluate the effi cacy of ah shi point and general acupuncture point treatment of acne vulgaris. Methods 36 subjects were recruited and randomised in a double-blind (patient-blind and observer-blind) controlled trial to receive acupuncture either at general acupuncture points only, or at both general acupuncture points and ah shi points 12 times over 6 weeks. The subjects were evaluated using the following outcome measurements: an infl ammatory lesion count, a quality-of-life scale (Skindex-29) and a subjective symptom score. Results After 12 treatment sessions, there was a signifi cant reduction in the infl ammatory acne lesion counts, the Skindex-29 scores and the subjective symptom scores from baseline in both groups, but no signifi cant difference between groups. Conclusions Acupuncture treatment of moderate acne vulgaris was associated with reduction of infl ammatory lesions and improvement of the quality of life.

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Section: Discussionmentioning

confidence: 99%

Efficacy of ah shi Point Acupuncture on Acne Vulgaris

2010

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“…Sebum overproduction due to sebaceous gland hyperplasia occurs firstly in IAV [17]. Also, the hair follicle hyperkeratinizes and prevents normal shedding of the follicular keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

Correlation of IL-8 and C - reactive protein Serum Levels with the Severity of Inflammatory Acne Vulgaris: a Comparative Study

Mohammed¹,

Mohammed²,

Abd-el-hamid³

et al. 2016

ARC Journal of Dermatology

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“…Acne vulgaris is a common skin disorder of the sebaceous follicles involving various pathogenic factors such as seborrhea 1 , ductal hypercornification of keratinocytes 2 stimulation of sebaceous gland secretion causing hormone imbalance, inflammation 3 and microbial colonization with Propionibacterium acnes 4 . P. acnes produce an exoenzyme lipase that hydrolyses sebaceous triglycerides, releasing free fatty acids causing irritation of the follicular wall and the surrounding dermis 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Novel Antipropionibacterium Activity of Embelin and Chebulagic Acid on Screening of Indian Medicinal Plants

Vijaya¹,

Dhunjibhoy²,

Dasgupta³

2017

Int. Res. J. Pharm.

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Modern antibiotics against acne vulgaris has led to resistance among Propionibacterium acnes. This may be overcome with the use of ancient Indian medicines documented against skin diseases. Methanolic extracts of 21 medicinal plants were screened for antipropionibacterium activity to provide a scientific basis for indigenous cures derived from traditional knowledge. Seven medicinal plants were found to inhibit the gr owth of P. acnes. Of these Embelia ribes, Salmalia malabarica and Terminalia chebula showed strong inhibitory effects. The novel antipropionibacterium activity of embelin isolated from Embelia ribes and chebulagic acid isolated from Terminalia chebula which strongly inhibited the growth of P. acnes with minimum inhibitory concentration of 12.5 μg/ml has been reported.

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Pathogenesis and Pathogenesis Related Treatment of Acne

Cited by 81 publications

References 47 publications

Efficacy of ah shi Point Acupuncture on Acne Vulgaris

Efficacy of ah shi Point Acupuncture on Acne Vulgaris

Correlation of IL-8 and C - reactive protein Serum Levels with the Severity of Inflammatory Acne Vulgaris: a Comparative Study

Novel Antipropionibacterium Activity of Embelin and Chebulagic Acid on Screening of Indian Medicinal Plants

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