Pathogenesis and Pathogenicity of Influenza Viruses

Kapoor, Sanjay; Dhama, Kuldeep

doi:10.1007/978-3-319-05512-1_8

Cited by 1 publication

(1 citation statement)

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“…We found that EEC could inhibit all the influenza viruses, including the oseltamivir-resistant H1N1 (H274Y) virus, on A549 cells at a similar efficiency (Figure 2). During infection of humans, the influenza virus can infect multiple cell types, including epithelial cells and monocytes that are important for the pathogenesis of influenza [24]. We next checked the antiviral effect of EEC on epithelial MDCK cells and monocytic U937 cells against both influenza virus A and B viruses.…”

Section: Eec Has a Broad Spectrum Of Antiviral Activity Against A Panel Of Influenza Viruses In A549 U937 And Mdck Cellsmentioning

confidence: 99%

Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo

Zhang

Chen

et al. 2020

Viruses

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Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there have been no effective drugs as yet to cure all patients infected by influenza viruses. Natural products from plants contain compounds with diverse structures that have the potential to interact with multiple host and virus factors. In this study, we identified the ethanol extract of Caesalpinia decapetala (Roth) Alston (EEC) as an inhibitor against the replication of a panel of influenza A and B viruses both on human pulmonary epithelial A549 and human monocytic U937 cells. The animal study revealed that EEC administration reduces the weight loss and improves the survival rate of mice infected with lethal influenza virus. Also, EEC treatment attenuated lung injury and reduced virus titer significantly. In conclusion, we showed that EEC has antiviral activity both in vitro and in vivo, suggesting that the plant C. decapetala has the potential to be further developed as a resource of new anti-influenza drugs.

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Section: Eec Has a Broad Spectrum Of Antiviral Activity Against A Panel Of Influenza Viruses In A549 U937 And Mdck Cellsmentioning

confidence: 99%