Pathogenesis And Symptomology Of The Exercise-hypogonodal Male Condition

Abstract

Men that engage in high volumes of long distance running have been previously shown to demonstrate low testosterone concentrations. However, both the cause and the consequences of the condition remain undetermined. The purpose of this study was to identify the pathogenesis of the condition as well as to determine whether symptoms that are typically seen in other populations with reduced testosterone are present. 9 men (Age: 36.3 ± 9.2 years; Height: 180.0 ± 8.8 cm; Weight: 77.2 ± 6.8 kg) performing an average of 81 ± 14 km per week of running for the past 12 months (EHMC) were compared to 8 men who served as control (CONT) subjects (Age: 30.8 ± 6.3 years; Height: 176.9 ± 5.2; Weight: 77.3 ± 10.7 kg) performing no regular exercise for the past 12 months. Blood samples were taken every 15 minutes beginning at 08:00 and continuing until 12:00, for a total of 17 blood draws. Blood was analyzed for testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and cortisol (C). Subjects underwent a dual x-ray absorptiometry (DEXA) scan to assess bone density and body composition. Subjects also completed the Aging Male Symptoms (AMS) questionnaire and a Food Frequency Questionnaire (FFQ). As expected, T concentrations were significantly (P ≤ 0.05) reduced in the EHMC group compared with CONT at all time points. There were no differences in LH. Dedication My Ph.D. is dedicated to my family. To my parents, Paul and Vanessa who gave me the opportunity and love I needed to pursue my dream. To my sister, Claire, for showing me that a Hooper can go to University. To my wife and children, Stephanie, Jace, Landon and Alexa. You were the inspiration for graduate school and the reason that I made it through. I love you all.