Pathogenesis of Acute Aortic Dissection: A Finite Element Stress Analysis

Patient-specific finite element analysis of ascending aorta aneurysms

“…Through finite element (FE) and fluid-structure interaction (FSI) analyses, it has been shown that the locations of peak wall stress correspond to common dissection initiation points just above the sinotubular junction (STJ) (24,29) and distal to the left subclavian ostium (24). The peak wall stress in aneurysms of the aortic arch is correlated to the overall aneurysm size as expected, but also the eccentricity, which may be a factor in the rupture of small aneurysms (4).…”

“…Aortic root motion and hypertension have also been shown to significantly increase the wall stress (1). The main limitations of these studies are the use of simplified, isotropic tissue properties, which are not patientspecific (1,4,24,25,29,36,39), idealized geometries (36,39), and lack of tissue failure criteria (1,4,24,25,29,36,39). In these studies, the peak vessel wall stress was the biomechanical index of interest; however, the accurate AsAA tissue properties and geometries, which can vary greatly among individuals, are necessary for accurate stress prediction.…”

“…Several groups have used computational methods to study thoracic aorta biomechanics (1,4,24,25,29,36,39). Through finite element (FE) and fluid-structure interaction (FSI) analyses, it has been shown that the locations of peak wall stress correspond to common dissection initiation points just above the sinotubular junction (STJ) (24,29) and distal to the left subclavian ostium (24).…”

Computational Analysis of the Mechanical Behaviors of Hemiarch and Total Arch Replacements

“…2,11,12,14,17,23 Aortic aneurysm rupture is generally believed to occur when the aortic wall stress exceeds the yield strength. Venkatasubramaniam et al 23 demonstrated that the peak wall stress, calculated from CT images and by finite element analysis, was significantly higher in a ruptured abdominal aortic aneurysm (AAA) than in a non-ruptured aneurysm.…”

“…17 Previous studies have focused on the pathogenesis of aortic dissection and the rupture risk stratification of abdominal and thoracic aortic aneurysms. 2,12,14,17,23 This study investigated the stress distribution in the aortic wall post-HAR and post-TAR, using a fluidstructure interaction model that combines computational fluid dynamics and structural analysis.…”