Pathogenesis of Alcoholic Liver Disease–Recent Advances

Nanji, Amin A.; Su, Grace L.; Laposata, Michael; French, Samuel W.

doi:10.1111/j.1530-0277.2002.tb02598.x

Cited by 19 publications

(10 citation statements)

References 60 publications

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“…It is becoming increasingly evident that alcohol enhances hepatic apoptosis in humans and in animal models of liver disease and when added to cultured hepatocytes. [15][16][17][18]20 Indeed, we showed significant increases in caspase-3 activity in hepatocytes and sinusoidal endothelial cells isolated from rats chronically fed alcohol for 14 weeks. 19,20 Also, we demonstrated that a pancaspase inhibitor can attenuate liver injury and apoptosis in alcohol-fed rats injected with lipopolysaccharide.…”

Section: Discussionmentioning

confidence: 69%

“…Apoptosis is increasingly recognized as a major mechanism for cell death in many forms of liver disease, including both experimental models of alcohol-related injury and human alcoholic liver disease. 9,[15][16][17][18][19][20] Recent studies suggest that apoptosis may lead to hepatic neutrophil infiltration (reviewed in Jaeschke et al 11 ). This seems somewhat paradoxical in that apoptosis is normally thought to lead to orderly, noninflammatory removal of dead cells.…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Proteasome Function Leads to Nf–κB–Independent Il–8 Expression in Human Hepatocytes

et al. 2003

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Inhibition of Proteasome Function Leads to Nf–κB–Independent Il–8 Expression in Human Hepatocytes

et al. 2003

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“…This may be because the female liver is more vulnerable to alcoholic injury than the male liver 41) , and such interactions may be attributable to greater vulnerability in female A227 carriers. In contrast, HDL-C levels showed no significant difference between the PPARA-V227A and PPARA-WT.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA‐V227A Polymorphism

Naito

Kamijima

Yamanoshita

et al. 2007

Journal of Occupational Health

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Differential Effects of Aging, Drinking andExercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism: Hisao NAITO, e t a l . D e p a r t m e n t o f O c c u p a t i o n a l a n d Environmental Health, Nagoya University Graduate School of Medicine-Peroxisome proliferatoractivated receptor α (PPAR α) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type (PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35-to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDL-C levels in the A227 carriers may be different from those in the PPARA-WT subjects. (J Occup Health 2007; 49: 353-362)

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“…The paraffin sections were cut on glass slides and stained with eosin for histopathological examination. The sections were examined under a light microscope to detect any damage to the tissue with 500 Â magnification (Nanji et al, 2002).…”

Section: Histopathological Studiesmentioning

confidence: 99%

Formulation and characterization of albumin microspheres containing norcantharidate for liver tumor targeting

Fang

Shen

et al. 2014

Drug Delivery

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The objectives of this study were first to encapsulate norcantharidate into albumin microspheres by the emulsion crosslinking method and second to characterize the microspheres in terms of the morphological examination, particle size, and encapsulation efficiency. The in vitro release of norcantharidate from the microspheres was studied by using the dialysis bag method. Pharmacokinetics and biodistribution studies were used to evaluate the advantages of microspheres than the conventional formulations. The microspheres prepared by crosslink emulsion were with uniform size, smooth surface, spherical shape, and disperse evenly. The particle size was uniform (13.3 ± 0.4 mm) and the encapsulation efficiency was 54.3 ± 4.18%. In vitro release indicated that the norcantharidate microspheres had a wellsustained release efficacy and fitted Korsmeyer's Peppas release model. In vivo studies showed that pharmacokinetics of norcantharidate microspheres could be described by the model of two-compartment after i.v. administration and had higher AUC inside liver and spleen than the injection group. No histological change occurred to the rat liver after the administration of norcantharidate microspheres.

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Pathogenesis of Alcoholic Liver Disease–Recent Advances

Cited by 19 publications

References 60 publications

Inhibition of Proteasome Function Leads to Nf–κB–Independent Il–8 Expression in Human Hepatocytes

Inhibition of Proteasome Function Leads to Nf–κB–Independent Il–8 Expression in Human Hepatocytes

Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA‐V227A Polymorphism

Formulation and characterization of albumin microspheres containing norcantharidate for liver tumor targeting

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