Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions

Naturally processed and HLA‐B8‐presented HPV16 E7 epitope recognized by T cells from patients with cervical cancer

“…This may be due to the fact that HLA-B8 and HLA-A1 are part of the 8.1 ancestral haplotype (HLA-A1, Cw7, B8, DR3, DQ2). 32,33 The HLA-B7 allele, which has previously been described to be associated with cervical neoplasia, 34 appears to be more frequent in patients with cervical cancer (29.36%) as compared to the control population (25.00%), but without any significance in the chi-square calculation.…”

Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans

“…44 Although FV16 did not influence TNFa or LTa production, 37 the 8.1 ancestral haplotype has been associated with higher TNFa production in vitro 39,45,46 and with multiple autoimmune diseases. 20,47 Clearly BAT1(intron10)*C and TNF-308*A do not tag the causative SNPs in Southern Africans.…”

Autoimmune Diseases: The Role of Environment and Gene Interactions

“…The immunologic profile of the asthmatic airways presents as proliferation and activation of helper T lymphocytes (CD4+) of the subtype T H 2 responsible for the allergic inflammation in atopic asthmatics. Upon stimulation these cells release a number of cytokines covering IL-4, agent for IgE synthesis, IL-5, essential for eosinophils' maturation, and IL-3 and granulocyte-macrophage colony-stimulating factor, GMCSF (Bolland and Ravetch 2000, Candore et al, 2002, Lang et al, 2010, Pollard et al 1997. In allergic as well as nonallergic individuals we observe populations of eosinophils in the airways with increased levels in asthmatics with allergies http://www.…”