Pathogenesis of chronic inflammatory processes in the maxillofacial area (peri-implantitis and periodontitis) and squamous cell carcinoma: similarities and differences (review)

Аванесов, А. М.; Седов, Ю. Г.; Balashova, M. E.

doi:10.17650/2222-1468-2019-9-1-79-84

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Имеются работы, содержащие результаты исследований уровня содержания ФНО в ротовой жидкости при хирургической патологии челюстно-лицевой области [31]. При этом только отдельные статьи посвящены анализу уровня содержания ФНО в сыворотке крови при травмах челюстно-лицевой области [32].…”

Section:  результаты и обсуждениеunclassified

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Pohodenko-Chudakova¹,

Али²

2022

Стоматология. Эстетика. Инновации

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Цель. На основании анализа сведений, представленных в специальной литературе, содержащих как экспериментальную, так и клиническую составляющие при исследовании вопросов определения фактора некроза опухоли (ФНО) в биологических средах организма, в том числе в ротовой жидкости (РЖ) у лиц с третьими молярами в полости рта и у пациентов с травматическими переломами нижней челюсти, выявить нерешенные задачи и определить направление дальнейшего исследования. Материалы и методы. Проведен анализ специальной литературы за последние 15 лет по вопросам определения ФНО в биологических средах организма, в том числе в РЖ у лиц с третьими молярами в полости рта и у пациентов с травматическими переломами нижней челюсти. Результаты. Выявлены единичные публикации, содержащие результаты анализа уровня содержания ФНО в РЖ у лиц с третьими молярами. Исследован уровень содержания ФНО в естественной биологической среде полости рта у лиц с острой болью после операции удаления третьего моляра; доказано, что послеоперационный отек и воспалительная контрактура жевательных мышц могут быть прогнозируемы на основании уровня содержания ФНО в РЖ. С учетом того, что присутствие третьих моляров в большинстве клинических ситуаций сопровождается воспалительно-деструктивными процессами, чаще поражениями периодонта, важными являются данные об уровне содержания ФНО в РЖ, провоцирующего процесс деструкции костной ткани путем активации остеокластической резорбции. Заключение. Изложенное обосновывает необходимость проведения исследования по определению уровня содержания ФНО в ротовой жидкости у пациентов с травматическими переломами нижней челюсти при наличии в полости рта третьих моляров и при их отсутствии. Purpose. To identify unsolved problems and determine the ways of the study according to the analysis of the information presented in the specialized literature containing experimental and clinical parts in the study of the issues of determining the tumor necrosis factor (TNF) in biological environments of the body, including in the oral fluid (OF) in patients with third molars in the oral cavity and in patients with traumatic fractures of the mandible. Materials and methods. The analysis of special literature for the last 15 years on the determination of TNF in biological environments of the body including in the OF in patients with third molars in the oral cavity and in patients with traumatic fractures of the lower jaw. Results. Few publications containing the results of the analysis of the level of TNF content in the RV in persons with third molars have been identified. The level of TNF content in the natural biological environment of the oral cavity was studied in patients with acute pain after surgery for the third molar removal and it was proved that postoperative edema and inflammatory contracture of the masticatory muscles can be predicted based on the level of TNF content in the OF. Taking into account that the presence of third molars in most clinical cases is accompanied by inflammatory and destructive processes, more often by periodontal lesions, data on the level of TNF content in the OF provoking the process of destruction of bone tissue by activating osteoclastic resorption are important. Conclusion. The mentioned above confirms the need to make a study to determine the mentioned indicator in patients with traumatic fractures of the lower jaw in the presence of third molars in the oral cavity and in their absence.

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Section:  результаты и обсуждениеunclassified

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Pohodenko-Chudakova¹,

Али²

2022

Стоматология. Эстетика. Инновации

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Diagnostic Significance of Proinflammatory Cytokines in Planning Dental Implantation in Patients with General Somatic Pathologies

Gus'kov,

Abdurakhmanova,

Nikiforov

et al. 2023

I.P. Pavlov Russian Medical Biological Herald

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INTRODUCTION: The current stage of development of dental implantology permits to perform a complete dental rehabilitation even in complicated clinical situations. However, there are some difficulties which prevent achievement of a high success of implantological treatment in certain somatic pathologies that manifest in the form of systemic inflammation, and present relative contraindications for implantation. Important general somatic pathologies include chronic obstructive pulmonary disease, atherosclerosis, non-insulin-dependent diabetes mellitus, osteoporosis, etc., they are associated with the risk of acute inflammatory response of an organism to surgical implantological intervention. The risk of unpredictable complications also increases because of insufficiently wide laboratory diagnostic spectrum for planning dental implantation that includes a biochemical blood test, coagulogram, reaction to the presence of specific infections and viral diseases. This list of diagnostic data is not always sufficient for a complete prognosis of success of planned treatment in patients with a complicated general somatic or dental status. Besides, the interrelation between dental chronic diseases and general somatic pathologies which in some cases have common etiopathogenetic factors, is often not taken into account, but without the adequate diagnostic range they often remain unnoticed and lead to persistent complications in different periods after completion of treatment. Development of technologies of surgical and orthopedic dentistry permits to provide full dental care to patients even with different pathologies of organs and systems. But in this case, of importance is extended laboratory diagnostics aimed at identification of factors of chronic systemic inflammation, vascular risk, bacterial threats, for example, evaluation of some interleukins, tumor necrosis factor, C-reactive protein. CONCLUSION: A complex of clinical, laboratory and instrumental diagnostic methods will permit to adequately evaluate risk for treatment failure and construct a prognostic tactics of complex therapy, thereby reducing the probability for unpredictable complications in dental implantation in patients with different somatic pathologies.

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Salivadiagnostics of the oral cavity in periodontitis and peri-implantitis using immunological methods. Review article

Dzhandarova,

Dolgalev,

Edisherashvili

et al. 2024

Medicinskij alfavit

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This article discusses current research methods of periodontitis and periimplantitis with the use of immunological diagnostic methods in relation to the hormonal balance of the body, the level of defensins and metalloproteinases. The main conclusions of studies of the composition of saliva in inflammatory periodontal diseases are presented. Salivadiagnostics is used not only as definitions of pathology of the oral cavity, but also of the whole organism as a whole.

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Pathogenesis of chronic inflammatory processes in the maxillofacial area (peri-implantitis and periodontitis) and squamous cell carcinoma: similarities and differences (review)

Cited by 3 publications

References 13 publications

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Diagnostic Significance of Proinflammatory Cytokines in Planning Dental Implantation in Patients with General Somatic Pathologies

Salivadiagnostics of the oral cavity in periodontitis and peri-implantitis using immunological methods. Review article

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