Pathogenesis of Fungal Infections

Banushree, Chandrasekhar Srinivasamurthy; S, Madhusudhan N

doi:10.1007/978-3-030-06088-6_4

Cited by 3 publications

(1 citation statement)

References 89 publications

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“…[ 15 ] PCM and neuroparacoccidioidomycosis (NPCM) are more prevalent in males in a 11:1 ratio. [ 1 , 16 , 17 ] In a systematic review, 93% of patients were male living in rural areas. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus

Kamer

Pretto

Livramento

et al. 2021

Surgical Neurology International

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Background: Brain paracoccidioidomycosis (PCM) or neuroparacoccidioidomycosis (NPCM) is a fungal infection of the central nervous system (CNS) caused by Paracoccidioides brasiliensis, a dimorphic fungus. The CNS involvement is through bloodstream dissemination. The association between NPCM and systemic lupus erythematous (SLE) is rare. However, SLE patients are under risk of opportunistic infections given their immunosuppression status. Case Description: The aim of this case report is to present a 37-year-old female with diagnosis of SLE who presented with progressive and persistent headache in the past 4 months accompanied by the right arm weakness with general and neurologic examination unremarkable. The computerized tomography of the head showed left extra-axial parietooccipital focal hypoattenuation with adjacent bone erosion. The brain magnetic resonance imaging reported left parietooccipital subdural collection associated with focal leptomeningeal thickening with restriction to diffusion and peripheral contrast enhancement. The patient underwent a left craniotomy and dura mater biopsy showed noncaseous granulomatosis with multinucleated giant cells with rounded birefringent structures positive for silver stain, consistent with PCM. Management with itraconazole 200 mg daily was started with a total of 12 months of treatment, with patient presenting resolution of headache and right arm weakness. Conclusion: The diagnosis of NPCM is challenging and a high degree of suspicious should be considered in patients with persistent headache and immunosuppression.

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Section: Introductionmentioning

confidence: 99%

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus

Kamer

Pretto

Livramento

et al. 2021

Surgical Neurology International

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In Vitro Models for Studying Respiratory Host–Pathogen Interactions

Barron

Sáez²,

Owens³

2021

Advanced Biology

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Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus‐2 pandemic, are of high and prevalent socio‐economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host–pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.

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Antimicrobial Activities of Satureja khuzestanica Jamzad; A Review

Mahmoudvand

Ezatpour

Masoori

et al. 2021

IDDT

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: Satureja khuzestanica Jamzad. is a species native to Iran, highly important in Southwestern regions. It belongs to the Lamiaceae family and grows in different climates. A number of pharmacological properties such as analgesic, anti-inflammatory, anticancer, anti-thyroid, antioxidant, and diuretic heve been attributed to this plant. In recent years, a wide range of biological properties, extract, and essential oil of Satureja khuzestanica has been studied by researchers. In the present study, Scopus, SID, ISI, Google Scholar, and PubMed indices were used to extract research articles. No publication time constraint was considered, and the keyword “Satureja khuzestanica” was used to search articles. All extracted articles were examined by two expert researchers and those on the biologic and fundamental science properties of this plan entered the study. Results showed that S. khuzestanica has extensive research and medicinal applications. Considering the economic and medical importance of S. khuzestanica, it is hoped that more extensive studies can be conducted in future on the use of compounds and derivatives of this plant in order to obtain herbal medications to treat pathogens in human and animal.

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Pathogenesis of Fungal Infections

Cited by 3 publications

References 89 publications

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus

In Vitro Models for Studying Respiratory Host–Pathogen Interactions

Antimicrobial Activities of Satureja khuzestanica Jamzad; A Review

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