Pathogenesis of human hemangiosarcomas and hemangiomas

Liu, Liping; Kakiuchi-Kiyota, Satoko; Arnold, Lora L.; Johansson, Sonny L.; Wert, David; Cohen, Samuel M.

doi:10.1016/j.humpath.2013.05.012

Cited by 45 publications

(64 citation statements)

References 29 publications

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“…A number of immunohistochemistry and immunofluorescence investigations have shed light on the cells of origin of these tumors and have influenced potential therapeutic targets (16)(17)(18)(19). Specifically, the expression levels of selected adhesion molecules, including VE-cadherin and PECAM-1 (CD31), have been implicated in the development of vascular tumors and may be correlated with their metastatic and malignant potentials (20,21).…”

Section: Discussionmentioning

confidence: 99%

Adhesion Molecule-Mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior

Madri

2014

Molecular and Cellular Biology

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Hemangioendotheliomas are categorized as intermediate-grade vascular tumors that are commonly localized in the lungs and livers. The regulation of this tumor cell's proliferative and apoptotic mechanisms is ill defined. We recently documented an important role for Hippo pathway signaling via endothelial cell adhesion molecules in brain microvascular endothelial cell proliferation and apoptosis. We found that endothelial cells lacking cell adhesion molecules escaped from contact inhibition and exhibited abnormal proliferation and apoptosis. Here we report on the roles of adherens junction molecule modulation of survivin and the Hippo pathway in the proliferation and apoptosis of a murine hemangioendothelioma (EOMA) cell. We demonstrated reduced adherens junction molecule (CD31 and VE-cadherin) expression, increased survivin and Ajuba expression, and a reduction in Hippo pathway signaling resulting in increased proliferation and decreased activation of effector caspase 3 in postconfluent EOMA cell cultures. Furthermore, we confirmed that YM155, an antisurvivin drug that interferes with Sp1-survivin promoter interactions, and survivin small interference RNA (siRNA) transfection elicited induction of VE-cadherin, decreased Ajuba expression, increased Hippo pathway and caspase activation and apoptosis, and decreased cell proliferation. These findings support the importance of the Hippo pathway in hemangioendothelioma cell proliferation and survival and YM155 as a potential therapeutic agent in this category of vascular tumors.

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Section: Discussionmentioning

confidence: 99%

Adhesion Molecule-Mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior

Madri

2014

Molecular and Cellular Biology

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“…Pathogenesis of these tumors is still unclear. Recently, their origin from late EPCs or differentiated endothelial cells was demonstrated [13]. EPCs are mobilized either from the bone marrow or the arterial area to replace dysfunctional endothelial cells and, using different molecular mechanisms, play a pivotal role in blood perfusion of ischemic and tumoral tissues [14–27].…”

Section: Discussionmentioning

confidence: 99%

Cavernous hemangioma of rhinopharynx: our experience and review of literature

et al. 2015

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Hemangiomas are benign tumors originating in the vascular tissues of skin, mucosa, muscles, glands, and bones. Although these tumors are common lesions of the head and neck, they rarely occur in the nasal cavity and paranasal sinuses. Cavernous haemangioma of the lateral wall of the nasopharynx has not previously been reported. We examined the clinical, radiological and therapeutic management of cavernous haemangioma of nasopharynx starting from a clinical case of a 26-year-old woman with a history of recurrent and conspicuous epistaxis and left-sided nasal associated severe obstruction. Nasopharynx examination, by flexible endoscopy, showed a cystic mass borne by the left side wall of the nasopharynx, in contact with the soft palate, covered by intact and regular mucosa. Contrast-enhanced computed tomography (CT) scan, confirmed these findings and showed contextual lamellar calcifications and inhomogeneous enhancement. The nasal endoscopic approach (FESS), under general anesthesia, allowed removal of the mass, without complications, after careful hemostasis of arterial branches. It was possible to establish the precise site of origin of the tumor only during the surgical procedure. Histopathological study showed mucosa with extensive vascular proliferation, with framework of lacunar/cavernous haemangioma, also present at lamellar bone tissue level. An unusual site and an unspecific clinical appearance can make diagnosis and treatment of a cavernous hemangioma of the nasopharynx difficult. The nasal endoscopic technique proved to be reliable in terms of adequate exposure and visualization of the lesion, control of bleeding, and complete removal of the mass.

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“…Pathogenesis of these tumors is still unclear. The origin of tumors of endothelial cells was recently demonstrated to be like hamangiomas and hemangiosarcomas from early or late EPCs [7]. EPCs are derived either from the bone marrow and/or the arterial wall to replace dysfunctional endothelial cells [8–12].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant hepatic epithelioid hemangioendothelioma (HEHE) is a rare variant with an incidence of <0.1 per 100,000 individuals worldwide usually appearing as multiple nodules involving both hepatic lobes and can be misdiagnosed on the basis of its radiologic patterns [1–6]. Origin and pathogenesis of these tumors should be well addressed but some tumors of endothelial cells like hamangiomas, hemangiosarcomas arise from early or late Endothelial Progenitor Cells (EPCs) [7]. Endothelial progenitors express several molecular markers and are involved in angiogenesis processes [8–12].…”

Section: Introductionmentioning

confidence: 99%

Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up

et al. 2015

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Malignant Hepatic Epithelioid hemangioendothelioma (HEHE) is an uncommon vascular tumor of intermediate malignant potential. HEHE is a rare tumor and it is difficult to diagnose for surgeons, hepatologists, radiologists and pathologists. So, misdiagnosis with a delay of the treatment is not uncommon.We describe a case of a young woman with a diagnosis of HEHE made 6 years after the first evidence of liver mass with a very long term follow-up after surgical treatment.She had two diagnoses of Hepatocellurar carcinoma (HCC) and a diagnosis of Cholangiocarcinoma after three different fine needle biopsies. After clinical observation, a new laparoscopic core biopsy was performed. In a first time approach, considering clinical and radiological patterns, a diagnosis of Budd-Chiari Syndrome was finally made.For that the patient underwent an orthotopicliver transplantation (OLTx).The surgical sample histological analysis allowed a definitive diagnosis of HEHE.At last, at follow up 7 years after three OLTx the patient is still alive and in good health with no evidence of recurrence.

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Pathogenesis of human hemangiosarcomas and hemangiomas

Cited by 45 publications

References 29 publications

Adhesion Molecule-Mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior

Adhesion Molecule-Mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior

Cavernous hemangioma of rhinopharynx: our experience and review of literature

Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up

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