Pathogenesis of malignant ascites in ovarian cancer patients

Stanojevic, Zorica; Rancic, Z; Radić, S; Potić-Zečević, Nataša; Djordjević, Biljana; Marković, Milan; Todorovska, Ilinka

doi:10.2298/aoo0402115s

Cited by 19 publications

(17 citation statements)

References 31 publications

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“…Th e presence of malignant ascites is a common and distressing complication of the human abdominal cancer with abdominal distension and changes in abdominal girth as the classic symptoms (Stanojevic et al 2004). Usually, malignant ascites is a sign of the peritoneal carcinomatosis (malignancies including ovarian, colorectal, pancreatic and uterine; extraabdominal tumors originating from lymphoma, lung and breast; and a small number of unknown primary tumors) and indicates the presence of malignant cells in the peritoneal cavity.…”

Section: Discussionmentioning

confidence: 99%

Effect of the autonomic nervous system on cancer progression depends on the type of tumor: solid are more affected then ascitic tumors

Horváthová

Mravec

2016

Endocrine Regulations

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Section: Discussionmentioning

confidence: 99%

Effect of the autonomic nervous system on cancer progression depends on the type of tumor: solid are more affected then ascitic tumors

Horváthová

Mravec

2016

Endocrine Regulations

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“…Subsequently, the cancer cells move to the upper abdominal space with the ascites and are trapped in the openings of the lymphatic vessels on the peritoneum (lymphatic stomata). The negative pressure caused by inspiration causes the cancer cells to blockade the lymphatic stomata and form metastatic lesions [11]. In humans, lymphatic stomata distributes mostly on the surface of the subdiaphragm.…”

Section: Discussionmentioning

confidence: 99%

Reappraisal of Mechanical Exfoliating Cytology for the Detection of Peritoneal Dissemination during the Surgical Staging of Epithelial Ovarian Carcinomas and Borderline Tumours

Asai‐Sato¹,

Oshiro

Yamanaka

et al. 2014

Acta Cytologica

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Objective: This study aimed to evaluate the usability of peritoneal swabbing cytology (PSC) with cotton swabs as an effective method for the detection of peritoneal metastasis during the staging laparotomy of epithelial ovarian carcinomas and borderline tumours (EOC/BT). Study Design: One hundred and ninety-two patients with EOC/BT who underwent laparotomy at the Yokohama City University Hospital from 2004 to 2010 were analysed retrospectively. The positive rates of the PSC and ascites/peritoneal-wash cytology (A/PWC) were compared. Results and Conclusion: Both A/PWC and PSC were performed during laparotomy (n = 140). The rate of metastasis detection with A/PWC was significantly higher than with PSC (50.0 vs. 20.7%, p < 0.001 by χ² test). The superior detection ability of A/PWC was observed regardless of the presence of macroscopic peritoneal metastasis in 56 cases with macroscopic peritoneal metastasis, with A/PWC detecting 80.3% of cases versus PSC detecting 37.5% (p = 0.013). In 84 cases without macroscopic peritoneal metastasis, A/PWC detected 29.8% of cases versus 9.5% with PSC (p = 0.003). Our results suggest that PSC is insufficient to evaluate the peritoneal metastasis for the surgical staging of EOC/BT. Other procedures such as subdiaphragmatic A/PWC should be included when possible to maximize the accuracy of diagnosis.

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“…The events that are definitely happening and that we are familiar with include an increase of net filtration and accumulation of ascitic fluid resulting from increased capillary permeability, increased surface area for filtration, increased hydraulic pressure difference, and decreased oncotic pressure difference [6].…”

Section: Pathophysiologymentioning

confidence: 99%

Ascitic Fluid in Ovarian Carcinoma – From Pathophysiology to the Treatment

Živadinović¹,

Petrić²,

Krtinić³

et al. 2017

Ascites - Physiopathology, Treatment, Complications and Prognosis

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Due to low symptomatology, a lack of screening, and relatively complicated diagnostic procedures of ovarian carcinoma, more and more women are believed to visit their doctors in advanced stage of the disease, complicated with ascitic fluid. There is an increasing evidence that peritoneal cytology is a subjective assessment with certain percentage of false-positive and false-negative results that may cause application of unnecessary chemotherapy or nonapplication of necessary chemotherapy. Maximal cytoreductive surgery followed by intraperitoneal or systemic chemotherapy remains to be the gold standard in preventing ascites. Ascites is not only a symptom of a disease, but a specific microenvironment for formation and mediation of protumorigenic signals that control ovarian cancer progression, proliferation, invasion, anti-apoptosis, chemoresistance and tumor heterogeneity. Acellular cytokines and immunological factors influence ovarian cancer progression and its ability to prevent immune responses of the body and tumor reaction to chemotherapy. Ascites contributes to disease dissemination, changing its course and final outcomes. Management of patients with ascites and ovarian carcinoma is complex and often the goal of the treatment is to target palliative procedures. Multidisciplinary approach is necessary in the management of these patients. Further investigations of new drugs and immunomodulators are needed aiming at prolonged periods between relapses.

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Pathogenesis of malignant ascites in ovarian cancer patients

Cited by 19 publications

References 31 publications

Effect of the autonomic nervous system on cancer progression depends on the type of tumor: solid are more affected then ascitic tumors

Effect of the autonomic nervous system on cancer progression depends on the type of tumor: solid are more affected then ascitic tumors

Reappraisal of Mechanical Exfoliating Cytology for the Detection of Peritoneal Dissemination during the Surgical Staging of Epithelial Ovarian Carcinomas and Borderline Tumours

Ascitic Fluid in Ovarian Carcinoma – From Pathophysiology to the Treatment

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