Pathogenesis of Mycotic Aneurysm

Nakata, Yusuke; Shionoya, Shigehiko; Kamiya, Kisaku

doi:10.1177/000331976801901003

Cited by 65 publications

(26 citation statements)

References 14 publications

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“…Experimental evidence supports the concept that disturbance of vasa vasorum may be a fundamental step in relation to bacteremia (Nakata et al, 1968).…”

Section: Introductionsupporting

confidence: 61%

“…Several mechanisms may be operating in their genesis (Nakata et al, 1968;Stengel and Wolferth, 1923;Weinstein, 1980;Wilson ef al., 1981): direct bacterial invasion of the arterial wall, embolic occlusion, and sterile infarction of the vasa vasorum, injury due to deposition of immune complexes. Experimental evidence supports the concept that disturbance of vasa vasorum may be a fundamental step in relation to bacteremia (Nakata et al, 1968).…”

Section: Introductionmentioning

confidence: 99%

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Extracranial mycotic aneurysms in infective endocarditis

Mansur

Grinberg

Leão

et al. 1986

Clinical Cardiology

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Nine of 217 (4.15%) patients with infective endocarditis who were followed from October 1978 to February 1984 had extracranial mycotic aneurysms (MA). Age range of patients was 6–43 years (mean of 24.8 years) and 7 were male. Etiologic agents were Streptococcus viridans (3 cases), Staphylococcus aureus (2 cases), Staphylococcus epidermidis (1 case), and Pseudomonas aeruginosa (1 case). Two patients had negative blood cultures. The MA involved the arteries of the limbs (5 cases), thoracic (3 cases), and abdominal (1 case) arteries. The diagnosis was made by means of physical examination (5 cases), chest roentgenogram (2 cases), ultrasound examination (1 case), and aortography (1 case), at hospital admission (2 cases), early or before antibiotic therapy (2 cases), and from two days to six months after finishing antibiotic therapy (5 cases). All but one patient were operated upon due to MA; bleeding occurred in three cases; surgery was an emergency procedure in one case and performed from 8 to 58 days after the diagnosis of the MA in the others. Signs of infection at surgery were found in one case. In the others, further antibiotic therapy was not administered. There were no limb losses in the peripheral MA. Four patients received surgical treatment for endocarditis. There was one in‐hospital death and another one 6 months later due to heart failure.

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“…Experimental evidence supports the concept that disturbance of vasa vasorum may be a fundamental step in relation to bacteremia (Nakata et al, 1968).…”

Section: Introductionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Extracranial mycotic aneurysms in infective endocarditis

Mansur

Grinberg

Leão

et al. 1986

Clinical Cardiology

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“…Such infected aneurysms are life-threatening because of their rapid expansion and predilection to rupture. Infected aneurysms can develop from hematogenous spread of infectious microemboli into the vasa vasorum of a normal-caliber artery or pre-existing aneurysm, infection of a pre-existing intimal defect by a circulating infectious agent, contiguous involvement of the vessel from an adjacent source of sepsis or direct infectious inoculation of the vessel wall at the time of vascular trauma [13]. Infectious arteritis causes destruction of the arterial wall with subsequent contained rupture and formation of a pseudoaneurysm.…”

Section: Discussionmentioning

confidence: 99%

Cause of internal hemorrhage determined after exhumation: Report of one case

Piercecchi-Marti

Léonetti

Rougé

et al. 2011

Forensic Science International

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“…6,7 The spectrum of causative microorganisms consisted mainly of Staphylococcus aureus, Salmonella species, and Streptococcus species. 8 As a pathogen, L. monocytogenes infects a wide range of host species and host cell types.…”

Section: Discussionmentioning

confidence: 99%

Listeria monocytogenes as a rare cause of mycotic aortic aneurysm

Bal

Schönleben

Agaimy

et al. 2010

Journal of Vascular Surgery

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Mycotic aneurysms represent a diagnostic and therapeutic challenge still lacking general recommendations for optimal therapy. So far, Listeria monocytogenes (L. monocytogenes) is very rarely reported to be the causative organism of mycotic aortic aneurysms. We report 2 cases of mycotic abdominal aortic aneurysms due to L. monocytogenes infection being treated by radical debridement, open in situ reconstruction with aorto-bi-iliac Dacron grafts, and long-term antibiotic therapy. Both patients recovered well from surgery. Interestingly, the long-time follow-up for the first patient 9 years after surgery was entirely uneventful. Open debridement in an in situ reconstruction with Dacron grafts followed by antibiotic therapy seems to be a suitable therapeutic regime for mycotic aneurysms due to L. monocytogenes.

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Pathogenesis of Mycotic Aneurysm

Cited by 65 publications

References 14 publications

Extracranial mycotic aneurysms in infective endocarditis

Extracranial mycotic aneurysms in infective endocarditis

Cause of internal hemorrhage determined after exhumation: Report of one case

Listeria monocytogenes as a rare cause of mycotic aortic aneurysm

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