Pathogenesis of myopic choroidal neovascularization: A systematic review and meta-analysis

Zhang, Xiu Juan; X, Chen; Tang, Fang; Szeto, Simon; Ling, X.; Lin, Zuan; Tham, Clement C.; Pang, Chi‐Pui; Chen, Li Jia; Yam, Jason C.

doi:10.1016/j.survophthal.2023.07.006

Cited by 4 publications

(1 citation statement)

References 88 publications

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“…Furthermore, local oxidative stress in the eye has previously been reported to be closely involved with mCNV. 19 , 20 , 21 , 22 , 23 , 24 Thus, though several theories, including mechanical, hemodynamic, and heredodegenerative theories, have been proposed to interpret the pathogenesis of mCNV, 1 , 25 , 26 the current results suggest that systemic oxidative stress could also potentially be a key player in mCNV and that the B/d ratio may be a promising predictive marker for mCNV risk.…”

Section: Discussionmentioning

confidence: 71%

Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

Wang,

Kunikata,

Yasuda

et al. 2024

Ophthalmology Science

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Section: Discussionmentioning

confidence: 71%

Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

Wang,

Kunikata,

Yasuda

et al. 2024

Ophthalmology Science

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Xenohormetic Phytochemicals Inhibit Neovascularization in Microphysiological Models of Vasculogenesis and Tumor Angiogenesis

Kpeli,

Conrad,

Bralower

et al. 2024

Advanced Biology

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Xenohormesis proposes that phytochemicals produced to combat stressors in the host plant exert biochemical effects in animal cells lacking cognate receptors. Xenohormetic phytochemicals such as flavonoids and phytoalexins modulate a range of human cell signaling mechanisms but functional correlations with human pathophysiology are lacking. Here, potent inhibitory effects of grapefruit‐derived Naringenin (Nar) and soybean‐derived Glyceollins (Gly) in human microphysiological models of bulk tissue vasculogenesis and tumor angiogenesis are reported. Despite this interference of vascular morphogenesis, Nar and Gly are not cytotoxic to endothelial cells and do not prevent cell cycle entry. The anti‐vasculogenic effects of Glyceollin are significantly more potent in sex‐matched female (XX) models. Nar and Gly do not decrease viability or expression of proangiogenic genes in triple negative breast cancer (TNBC) cell spheroids, suggesting that inhibition of sprouting angiogenesis by Nar and Gly in a MPS model of the (TNBC) microenvironment are mediated via direct effects in endothelial cells. The study supports further research of Naringenin and Glyceollin as health‐promoting agents with special attention to mechanisms of action in vascular endothelial cells and the role of biological sex, which can improve the understanding of dietary nutrition and the pharmacology of phytochemical preparations.

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Scoping review of nonsurgical treatment options for macular holes

Lee,

Bahrami,

Selva

et al. 2024

Survey of Ophthalmology

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Pathogenesis of myopic choroidal neovascularization: A systematic review and meta-analysis

Cited by 4 publications

References 88 publications

Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

Xenohormetic Phytochemicals Inhibit Neovascularization in Microphysiological Models of Vasculogenesis and Tumor Angiogenesis

Scoping review of nonsurgical treatment options for macular holes

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