Pathogenesis of Normal-appearing White Matter Damage in Neuromyelitis Optica: Diffusion-Tensor MR Imaging

Yu, Chunshui; Lin, Fuchun Joseph; Jiang, Tianzi; Qin, Wen; Sun, Hong; Chan, Piu

doi:10.1148/radiol.2461062075

Cited by 86 publications

(84 citation statements)

References 25 publications

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“…40,41 Similarly, decreased FA and AD and increased RD have been demonstrated in patients with neuromyelitis optica. 42,43 These changes involve multiple, major WM tracts in the normal-appearing WM, accumulate with increasing disease duration, and are probably related to both demyelination and Wallerian degeneration. 42,43 A global decrease in WM integrity throughout the brain was observed in multiple major fiber tracts that control a wide range of brain functions.…”

Section: Discussionmentioning

confidence: 99%

“…42,43 These changes involve multiple, major WM tracts in the normal-appearing WM, accumulate with increasing disease duration, and are probably related to both demyelination and Wallerian degeneration. 42,43 A global decrease in WM integrity throughout the brain was observed in multiple major fiber tracts that control a wide range of brain functions. The CNS manifestations in pSS are heterogeneous, manifested as focal or diffuse involvement.…”

Section: Discussionmentioning

confidence: 99%

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White Matter Water Diffusion Changes in Primary Sjogren Syndrome

Tzarouchi¹,

Zikou²,

Tsifetaki³

et al. 2013

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

White Matter Water Diffusion Changes in Primary Sjogren Syndrome

Tzarouchi¹,

Zikou²,

Tsifetaki³

et al. 2013

American Journal of Neuroradiology

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show abstract

“…These methods have shown that ADEM, NMO and Leber optic neuropathy are associ ated with less diffuse tissue damage than is typical of MS, and this factor could be used as a distinguishing feature. [35][36][37][38] However, prospective studies are required to systematically assess the advantages of advanced techniques over conventional MRI in the diagnosis and prognosis of MS, and in the facilitation of prompt treatment decisions.…”

Section: -34mentioning

confidence: 99%

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

et al. 2015

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| The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal experience of the members of the MAGNIMS (Magnetic Resonance Imaging in MS) network. We address the indications, timing, coverage, reporting and interpretation of MRI studies in patients with suspected MS. Our recommendations are intended to help radiologists and neurologists standardize and optimize the use of MRI in clinical practice for the diagnosis of MS.

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“…Such areas are better evaluated with advanced MR imaging techniques, such as diffusion tensor MR imaging (DTI). This technique allows the assessment of tissues at a cellular level, once the microstructural architecture preservation of the white matter tracts are evaluated by water molecular diffusion along the axon fibers 6,7 . The DTI consists of three eigenvectors and to each one there is a corresponding diffusion axis that reports to the direction of diffusive water motion.…”

Section: Diffusion Tensor Magnetic Resonance Imaging May Show Abnormamentioning

confidence: 99%

Diffusion tensor magnetic resonance imaging may show abnormalities in the normal-appearing cervical spinal cord from patients with multiple sclerosis

Miraldi

Lopes²,

Costa³

et al. 2013

Arq. Neuro-Psiquiatr.

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Objective: This study aims to evaluate "in vivo" the integrity of the normal-appearing spinal cord (NASC) in patients with multiple sclerosis (MS) compared to controls, using diffusion tensor MR imaging. Methods: We studied 32 patients with MS and 17 without any neurologic disorder. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) were calculated within regions of interest at C2 and C7 levels in the four columns of the spinal cord. Results: At C2, FA value was decreased in MS patients. Besides, RD value was higher in MS than in controls. At C7, MD values were increased in MS. Conclusion: The NASC in the right column of the cervical spinal cord showed abnormal FA, RD and MD values, which is possibly related to demyelination, since the FA abnormality was related to the RD and not to the AD.Key words: diffusion tensor imaging, multiple sclerosis, cervical spinal cord. RESUMOObjetivo: Este estudo avalia "in vivo" a integridade da medula espinhal cervical aparentemente normal (MEAN) em pacientes com esclerose múltipla (EM) comparados aos controles, usando a imagem por tensor de difusão. Métodos: Foram selecionados 32 pacientes com EM e 17 controles. Foram calculadas fração anisotrópica (FA), difusão axial (DA), difusão radial (DR) e difusibilidade média (DM) dentro das regiões de interesse nos níveis C2 e C7 nas quatro colunas da medula espinhal. Resultados: Em C2, o valor de FA foi reduzido em pacientes com EM. Além disso, o valor da DR se mostrou mais elevado na EM do que nos controles. Em C7, os valores de MD foram maiores na EM. Conclusão: A MEAN na coluna direita da medula cervical mostrou valores alterados de FA, RD e MD, possivelmente relacionados à desmielinização, uma vez que a alteração de FA está relacionada à DR e não à DA.Palavras-Chave: imagem por tensor de difusão, esclerose múltipla, medula cervical.

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Pathogenesis of Normal-appearing White Matter Damage in Neuromyelitis Optica: Diffusion-Tensor MR Imaging

Abstract: http://radiology.rsnajnls.org/cgi/content/full/2461062075/DC1.

Cited by 86 publications

References 25 publications

White Matter Water Diffusion Changes in Primary Sjogren Syndrome

White Matter Water Diffusion Changes in Primary Sjogren Syndrome

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

Diffusion tensor magnetic resonance imaging may show abnormalities in the normal-appearing cervical spinal cord from patients with multiple sclerosis

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