Pathogenesis of Osteoporosis

Saedi, Ahmed Al; Stupka, Nicole; Duque, Gustavo

doi:10.1007/164_2020_358

Cited by 18 publications

(9 citation statements)

References 79 publications

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“…OP is a complex pathophysiological process that depends on the amount of differentiation of BMSCs towards osteoblasts and the ability of different cells such as osteoblasts and osteoclasts to survive (23)(24)(25)(26)(27). miR-19b-3p had been linked to IGF-1, as well as to BMSCs based on increased levels of miR-19b-3p and decreased levels of IGF-1 in BMSCs of OP rats.…”

Section: The Inhibition Of Mir-19b-3p Promoted the Expression Of Oste...mentioning

confidence: 99%

Down-regulation of miR-19b-3p enhances IGF-1 expression to induce osteoblast differentiation and improve osteoporosis

Cai

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This research was conducted in order to investigate the role of miR-19b-3p in the development of osteoporosis (OP) in rats and the associated mechanisms. This study measured the expression levels of miR-19b-3p and IGF-1 in clinical OP patients and ovariectomy-induced OP rats by qRT-PCR. The osteoprotegerin levels in OP patients were measured by enzyme-linked immunosorbent assay (ELISA). The binding site of miR-19b-3p to IGF-1 was predicted by three prediction sites: Target Scan, miRDB and starbase. Experiments were conducted in vitro and in vivo using bone marrow mesenchymal stem cells (BMSCs) and OP rats, respectively, to verify the regulatory relationship between miR-19b-3p and IGF-1 and explore the role of miR-19b-3p in the development of OP. Results showed that the expression of miR-19b-3p was elevated in OP patients and rats, while IGF-1 expression was decreased (***p<0.001). The ELISA assay found that osteoprotegerin levels were inversely correlated with miR-19b-3p and positively correlated with IGF-1. The predictive analysis identified binding sites for miR-19b-3p to IGF-1. The potential regulatory relationship between miR-19b-3p and IGF-1 was validated by in vitro and in vivo experiments. Moreover, the important role of miR-19b-3p in the regulation of OP was further demonstrated. It was concluded the inhibition of miR-19b-3p has a suppressive effect on the development of OP and the function of miR-19b-3p in OP is likely to be achieved by regulating the expression of the IGF-1 gene.

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Section: The Inhibition Of Mir-19b-3p Promoted the Expression Of Oste...mentioning

confidence: 99%

Down-regulation of miR-19b-3p enhances IGF-1 expression to induce osteoblast differentiation and improve osteoporosis

Cai

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…Frail individuals present particularly high rates of osteoporosis [ 250 , 251 ]. Two different mechanisms may be behind the weakened bones in older people: increased bone resorption and deficient bone formation [ 252 ]. Bone homeostasis is maintained by equilibrating the creation of new bone and bone breakdown, which relies on osteoclasts and osteoblasts.…”

Section: Age-associated Diseases: Implication Of the Nlrp3 Inflammmentioning

confidence: 99%

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

Sebastian-Valverde

Pasinetti

2020

Cells

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As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from a broad spectrum of diseases need to be better understood. However, one specific shared feature seems to be of capital relevance for most of these conditions: the low-grade chronic inflammatory state inherently associated with aging, i.e., inflammaging. Here, we review the molecular and cellular mechanisms that link aging and inflammaging, focusing on the role of the innate immunity and more concretely on the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, as well as how the chronic activation of this inflammasome has a detrimental effect on different age-related disorders.

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“…Marrow fat tissue is implicated in bone health, metabolism, and hematological diseases. Elucidating the importance of fat infiltration in the bone marrow niche in osteoporosis pathophysiology would extend our understanding of bone quality and the mechanisms that underpin osteoporosis 24 . Quantitative MRI can provide surrogate metrics for these features 25 .…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Ferritin With Marrow Iron Concentration Using a Three-Dimension Fat Analysis & Calculation Technique Sequence in Postmenopausal Women

Zheng

Wang

et al. 2022

J Comput Assist Tomogr

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ObjectiveThe aim of the study was to determine whether serum iron and ferritin levels are determinants of iron accumulation in bone marrow using a three-dimension Fat Analysis & Calculation Technique (FACT) sequence.MethodsWe measured spinal marrow R2* using a 3T FACT sequence in 112 postmenopausal women (mean age, 62.6 years; range, 50–82.6 years). Serum iron and ferritin levels were determined in blood specimens. Lumbar spine bone mineral density was measured by dual-energy x-ray absorptiometry. The levels of serum iron and ferritin were evaluated in relation to the spinal marrow R2* values before and after adjustments for potential confounders.ResultsIn the unadjusted model, magnetic resonance imaging–based spinal marrow R2* was positively correlated to the levels of serum ferritin (Spearman ρ = 0.436, P < 0.001) and iron (Spearman ρ = 0.245, P = 0.009). Multiple stepwise linear regression analyses (adjusting for age, years since menopause, body mass index, alcohol intake, tobacco use, physical activity, serum lipids profile, biomarkers of bone turnover, and lumbar spine bone density) were performed in 3 separate models with marrow R2* values as potential explanatory variables. The level of serum ferritin, but not iron, was an independent predictor of marrow R2* (standardized β coefficient, 0.302, 95% confidence interval, 0.141–0.509, P = 0.001). Similarly, spinal marrow R2* increased with a linear trend from the lowest (<139 ng/mL) to highest (≥180 ng/mL) serum ferritin quartiles (P for trend = 0.007).ConclusionsQuantitative assessment of R2* derived from FACT is a fast, simple, noninvasive, and nonionizing method to evaluate marrow iron accumulation.

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Pathogenesis of Osteoporosis

Cited by 18 publications

References 79 publications

Down-regulation of miR-19b-3p enhances IGF-1 expression to induce osteoblast differentiation and improve osteoporosis

Down-regulation of miR-19b-3p enhances IGF-1 expression to induce osteoblast differentiation and improve osteoporosis

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

Association of Serum Ferritin With Marrow Iron Concentration Using a Three-Dimension Fat Analysis & Calculation Technique Sequence in Postmenopausal Women

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