Pathogenesis of platinum-induced peripheral neurotoxicity: Insights from preclinical studies

Calls, Aina; Carozzi, Valentina Alda; Navarro, Xavier; Monza, L; Bruna, Jordi

doi:10.1016/j.expneurol.2019.113141

Cited by 59 publications

(65 citation statements)

References 145 publications

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“…There are many possible therapies for the treatment of PIPN although none of them is completely efficient. That is the main reason for numerous investigations, presented in Table 2 , aiming to develop promising adjuvant therapy for PIPN, without interfering with platinum cytostatic activity [ 96 , 97 ].…”

Section: Antioxidants In the Treatment Of Platinum-based Chemothermentioning

confidence: 99%

Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics—A Review

Stanković

Selaković

Mihailović

et al. 2020

IJMS

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Cancer represents one of the most pernicious public health problems with a high mortality rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches for the treatment of various malignancies. Platinum-based drugs (cisplatin, oxaliplatin, carboplatin, etc.) are highly effective chemotherapeutic drugs used for the treatment of several types of malignancies, but their application and dosage are limited by their toxic effects on various systems, including neurotoxicity. Simultaneously, researchers have tried to improve the survival rate and quality of life of cancer patients and decrease the toxicity of platinum-containing drugs by combining them with non-chemotherapy-based drugs, dietary supplements and/or antioxidants. Additionally, recent studies have shown that the root cause for the many side effects of platinum chemotherapeutics involves the production of reactive oxygen species (ROS) in naive cells. Therefore, suppression of ROS generation and their inactivation with antioxidants represents an appropriate approach for platinum drug-induced toxicities. The aim of this paper is to present an updated review of the protective effects of different antioxidant agents (vitamins, dietary antioxidants and supplements, medicaments, medicinal plants and their bioactive compounds) against the neurotoxicity induced by platinum-based chemotherapeutics. This review highlights the high potential of plant antioxidants as adjuvant strategies in chemotherapy with platinum drugs.

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Section: Antioxidants In the Treatment Of Platinum-based Chemothermentioning

confidence: 99%

Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics—A Review

Stanković

Selaković

Mihailović

et al. 2020

IJMS

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“…Так, цисплатин вызывает изменения в экспрессии факторов регуляции клеточного цикла клеток спинальных ганглиев, таких как циклин D1, p21, и опосредует гиперфосфорилирование продукта гена ретинобластомы. Дисрегуляция клеточного цикла может привести к попытке повторного вступления в клеточный цикл с бóльшим количеством неотрепарированной ДНК, вызывая, таким образом, апоптоз [17].…”

Section: нейротоксические осложнения химиотерапии: изучение причин и unclassified

Neurotoxic Complications of Chemotherapy in Children. Literature Review

et al. 2020

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The article provides the review of literature on the issue of neurotoxic complications of chemotherapy in children. The data search was carried out in the PubMed, CyberLeninka, RSCI databases and others. There are many works devoted to studying the distribution, structure, and clinical features of chemo-induced neurological disorders in modern literature. In general, analysis of literature has shown that the incidence of neurotoxic complications varies widely depending on the research methods and used chemo-therapeutic drugs. Manifestations of chemotherapy-induced neurological disorders are quite diverse and accompanied by the central and peripheral nervous system damage. However, it has been shown that the platinum-based drugs have effective ototoxic effect with the damage of the auditory nerve. The Vincristine often causes peripheral polyneuropathy. Methotrexate and Ifosfamide cause metabolic encephalopathy. Cytarabine's neurotoxicity is the damage of the cerebellum. The addition of neurological symptoms leads to decrease in the quality of life of patients. Some studies present the results of study of the causes and pathogenetic manifestations of neurotoxic reactions, changes in the genome associated with the development of specific toxic effects are identified. Despite the fact that many pathogenetic mechanisms of chemotherapy-induced neurotoxic complications have been revealed, the significance of laboratory predictors for prognosing and early assessment of these complications has not been essentially established yet, thus, there is the need for further study of this topic.

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“…L'allodynie 2 provoquée par des températures froides est un effet secondaire aigu spécifique de l'utilisation de l'oxaliplatine. Les autres symptômes neurologiques sensoriels sont des paresthésies 3 Cependant, les mécanismes par lesquels la molécule passerait des vaisseaux sanguins vers les axones, au niveau des nerfs périphériques, restent encore non élucidés mais ne sont pas à exclure. En effet, les données disponibles sur les mécanismes d'action de l'oxaliplatine menant aux symptômes de la NPCI consistent essentiellement en une description de ses effets sur les neurones et ne discute pas du potentiel rôle de « porte d'entrée » des vaisseaux intra-nerveux.…”

Section: Les Mécanismes Connus à L'origine De La Neurotoxicité De L'ounclassified

“…La production d'espèces réactives de l'oxygène (ROS, pour reactive oxygen species) est augmentée, ce qui augmente le stress oxydatif intracellulaire. Les molécules d'oxaliplatine hydratées se liant également aux molécules nucléophiles comme le glutathion, elles provoquent une déplétion des réserves d'antioxydants et participent aussi à l'augmentation de la concentration de ROS intracellulaire [3]. Enfin, des cellules immunitaires sont activées (macrophages, lymphocytes T et monocytes) et des cytokines pro-inflammatoires sont produites.…”

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