Pathogenesis of Radiation and Virus-Induced Bone Tumors

Finkel, Miriam P.; Reilly, Christopher A.; Biskis, Birute O.

doi:10.1007/978-3-642-80997-2_7

Cited by 30 publications

(15 citation statements)

References 24 publications

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“…DISCUSSION We describe here the isolation and partial characterization of an osteoma-inducing retrovirus isolated from the skeletons of old osteoma-bearing 101 strain mice. The data obtained support the concept of the viral aetiology of this type of bone tumour which was first recognized by cellfree transmission studies in CF-1 mice (Finkel et al, 1976). CF-1 mice, like I01 mice, show a fairly high natural incidence of osteomas of about 20 ~ .…”

Section: Rnase T1 Fingerprints Of Oa Mulv C and Oa Mulvn Rnassupporting

confidence: 83%

Oncogenic Retrovirus from Spontaneous Murine Osteomas. I. Isolation and Biological Characterization

Schmidt

Erfle

Pedersen

et al. 1984

Journal of General Virology

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SUMMARYSpontaneous osteomas in strain 101 mice, a strain which has a high incidence of benign bone tumours, harbour numerous C-type virus-like particles with pleomorphic characteristics. A cell-free extract from osteomas from two mice induced bone tumours, together with osteopetrosis and lymphomas, in newborn mice of the low incidence NMRI strain after a latent period of 12 to 15 months. When C3H embryo fibroblasts were infected with the osteoma extract, the resulting cell line produced virus (OA MuLVc) with a high titre. OA MuLV c was cloned by serial endpoint dilution and NIH 3T3 cells were productively infected. The resulting virus was named OA MuLVN. OA MuLV c and OA MuLVN also induced bone tumours, osteopetrosis and lymphomas 12 to 15 months after injection into newborn NMRI mice. The isolated virus showed typical characteristics of the murine retrovirus group. Fv-1 host range restriction assays classified the viruses as N-ecotropic and XC-positive. Tryptic p30 peptide analysis and RNase T1 fingerprint analysis of OA MuLVc and OA MuLVy indicated that OA MuLVc contains an Akv-like virus as well as additional components, whereas OA MuLVN is closely related to Akv, but not identical to it. Serological analysis of the envelope proteins using monoclonal antibodies also showed the virus to be similar, but not identical, to Akv virus.

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Section: Rnase T1 Fingerprints Of Oa Mulv C and Oa Mulvn Rnassupporting

confidence: 83%

Oncogenic Retrovirus from Spontaneous Murine Osteomas. I. Isolation and Biological Characterization

Schmidt

Erfle

Pedersen

et al. 1984

Journal of General Virology

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“…The C-terminal of the UBiL domain contains the Gly-Gly dipeptide (Monia et al, 1990), a conserved feature of ubiquitin and ubiquitinlike proteins, which is required for protein conjugation with acceptor proteins (Mourtada-Maarabouni et al, 2004).fau, originally isolated from a radiation-induced osteosarcoma (Finkel et al, 1976), is inversely inserted as the fox sequence in FBR-MuSV (Van Beveren et al, 1984;Olvera and Wool, 1993). Expression of fox increases the transforming capability of FBR-MuSV, presumably by inactivating fau expression (Michiels et al, 1993).…”

Section: Discussionmentioning

confidence: 96%

Hc-fau, a novel gene regulating diapause in the nematode parasite Haemonchus contortus

Yan

Guo

Zhou

et al. 2014

International Journal for Parasitology

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“…A viral origin was suggested by the evidence that bone sarcomas can be induced in selected animals by viruses or cell-free extracts of human osteosarcomas [4]. The only environmental agent known to cause osteosarcoma in human is ionising radiation [4]. Radiation is implicated in approximately 2% of osteosarcomas.…”

Section: Etiologymentioning

confidence: 99%

Osteosarcoma (Osteogenic sarcoma)

Picci

2007

Orphanet J Rare Dis

391

327

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Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells. The classic osteosarcoma is a rare (0.2% of all malignant tumours) highly malignant tumour, with an estimated incidence of 3 cases/million population/year. Osteosarcoma arises predominantly in the long bones and rarely in the soft tissues. The age at presentation ranges from 10 to 25 years of age. Plain radiographs, computed tomography, magnetic resonance imaging, angiography and dynamic bone scintigraphy are used for diagnosis, evaluation the extent of tumour involvement and decision of the type of operation and, if necessary, the type of reconstruction. Years ago, all patients with osteosarcoma were treated by amputation but the cure rate was under 10% and almost all patients died within a year from diagnosis. Today, for localised osteosarcoma at onset (80% of cases) treated in specialized bone tumour centres with pre-and postoperative chemotherapy associated with surgery, the percentage of patients cured varies between 60% and 70%. Surgery is conservative (limb salvage) in more than 90% of patients. Prognosis is more severe (cure rate about 30%) for tumours located in the axial skeleton and in patients with metastasis at onset.

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Pathogenesis of Radiation and Virus-Induced Bone Tumors

Cited by 30 publications

References 24 publications

Oncogenic Retrovirus from Spontaneous Murine Osteomas. I. Isolation and Biological Characterization

Oncogenic Retrovirus from Spontaneous Murine Osteomas. I. Isolation and Biological Characterization

Hc-fau, a novel gene regulating diapause in the nematode parasite Haemonchus contortus

Osteosarcoma (Osteogenic sarcoma)

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