2020
DOI: 10.1016/j.cell.2020.05.027
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Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2

Abstract: Highlights d SARS-CoV-2 could infect HFH4-hACE2 mice and cause death d SARS-CoV-2 infection localizes to lungs of mice and causes typical interstitial pneumonia d Pre-exposure to SARS-CoV-2 protects mice from lethal challenge

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Cited by 570 publications
(642 citation statements)
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“…We anticipate that in animals expressing ACE2 receptors competent for S binding, a single dose of VSV-eGFP-SARS-CoV-2 will be associated with greater immunogenicity, and not require a second immunization for protection. To test this hypothesis, immunization and challenge studies are planned in hACE2 transgenic mice (Bao et al, 2020;Jiang et al, 2020;Sun et al, 2020) as they become widely available, and in hamsters and NHPs.…”
Section: Discussionmentioning
confidence: 99%
“…We anticipate that in animals expressing ACE2 receptors competent for S binding, a single dose of VSV-eGFP-SARS-CoV-2 will be associated with greater immunogenicity, and not require a second immunization for protection. To test this hypothesis, immunization and challenge studies are planned in hACE2 transgenic mice (Bao et al, 2020;Jiang et al, 2020;Sun et al, 2020) as they become widely available, and in hamsters and NHPs.…”
Section: Discussionmentioning
confidence: 99%
“…Preliminary studies report that this virus may infect ferrets, hamsters, and cats, inducing mild symptoms, but not pigs or birds (Chan et al, 2020;Shi et al, 2020). Interestingly, a very recent preliminary study shows that mice overexpressing human ACE2 may develop COVID-19-like signs in response to infection with SARS-CoV-2 (Jiang et al, 2020). These animals showed different F I G U R E 1 Possible role of ACE/ACE2 ratio in therapies against COVID-19 in the two sexes.…”
Section: Sex Cardiovascular Disease and Covid-19mentioning
confidence: 99%
“…To address these questions, we plan to continue studies that will inform whether LNP-delivered hsACE2 can inhibit live SARS-CoV-2 in vitro. For in vivo validation, we intend to use hACE2-transgenic animals that express similar pathogenesis when infected with the SAR-CoV-2 37,38 . With the further characterization variants that bind the RBD of SARS-CoV-2 or other hACE2-exploiting coronaviruses that may spill in the future.…”
Section: Mainmentioning
confidence: 99%