Pathogenesis of the Chikungunya virus and the host immunity response

Ahmed, Tasnia; Abdullah, Syed Mohamad Syed; Tanvir, Rehman; Nahar, Zobayda; Tasnim, Nishat; Saha, Chandrika; Noor, Rashed

doi:10.53388/life2021-1229-301

Cited by 1 publication

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“…CHIKV is transmitted through mosquito bites, and after going through the dermis and epidermis layers of the skin, the virus then attaches to fibroblasts, starting the replication process [127]. When CHIKV enters the skin of a human, it includes saliva from the bite of a mosquito, which may alter how the body responds to the virus, as was examined in a study by Agarwal et al [128].…”

Section: Cutaneous and Mucocutaneous Presentationsmentioning

confidence: 99%

Chikungunya Immunopathology as It Presents in Different Organ Systems

Traverse

Millsapps

Underwood

et al. 2022

Viruses

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Chikungunya virus (CHIKV) is currently an urgent public health problem as high morbidity from the virus leaves populations with negative physical, social, and economic impacts. CHIKV has the potential to affect every organ of an individual, leaving patients with lifelong impairments which negatively affect their quality of life. In this review, we show the importance of CHIKV in research and public health by demonstrating the immunopathology of CHIKV as it presents in different organ systems. Papers used in this review were found on PubMed, using “chikungunya and [relevant organ system]”. There is a significant inflammatory response during CHIKV infection which affects several organ systems, such as the brain, heart, lungs, kidneys, skin, and joints, and the immune response to CHIKV in each organ system is unique. Whilst there is clinical evidence to suggest that serious complications can occur, there is ultimately a lack of understanding of how CHIKV can affect different organ systems. It is important for clinicians to understand the risks to their patients.

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Section: Cutaneous and Mucocutaneous Presentationsmentioning

confidence: 99%