Pathogenesis of Uremia

Are Recent Findings on 1,25-Dihydroxycholecalciferol Metabolism Relevant for the Pathogenesis of Uremia?

“…We want to propose as a working hypothesis that some facets of uremia are not due to retention of renal excretory products or toxins [97], but to deficiency of the renal endocrine product l,25-(OH)2D3. In view of the observa tions described, it appears certainly rewarding to ex amine whether deficiency of l,25-(OH)2D3 plays a role in the genesis of some of the hormonal, myopathic, cutane ous, cardiovascular, hematologic or immune dysfunc tions of uremia.…”