Pathogenetic Influences of Human Herpesvirus 8 (HHV-8) in Prostate Cancer Progression

Abstract

The mechanisms that give rise to androgen-independent prostate cancer (AIPC) are incompletely understood, resulting in a lack of treatment options for this fatal form of the disease. It is believed that most cases of AIPC are the result of constitutive activation of the androgen receptor (AR) pathway, leading us to hypothesize that chronic, prostatic infection could promote cancer progression as a result of pathogen virulence factors activating cell signaling pathways known to induce AR signaling. We found that human