Pathogenetic Mechanisms of Experimental Gingivitis Progression Under the Influence of Lipopolysaccharide

Abstract

The paper presents the results of patogenetic rationale for the use of gel with lipopolysaccharide for gingivitis modelling. It shows, that lipopolysaccharide applications lead to significant increase in activity of elastase by 26.8%, malonic dialdehyde by 32.8%, urease by 78.9%, degree of dysbiosis by 32.6%, decrease in activity of lysozyme by 57.6% and antioxidant-prooxidant index by 29.7%. Thus, lipopolysaccharide application leads to the progression of inflammation processes in gums of experimental animals, dysbiosis and oxidative stress, that is pathogenetic links of gingivitis progression in humans as well.

Dynamics of Mineral Metabolism and Bone Metabolism in the Blood of Patients With Generalized Periodontitis With Different Reactivity of the Organism

“…tistry due to their massive spread and steady increase in working-age young people [1][2][3]. According to modern concepts, the process of bone remodeling depends on bone resorption and on the rate of bone formation and the ability of osteoblasts to form a full-fledged new bone, which is directly related to the state of bone metabolism and calcium-phosphorus homeostasis [4].…”

“…Запально-деструктивні процеси в тканинах пародонту є однією з центральних проблем стоматології, що пов′язано з їх масовим поширенням та неухильним зростанням у осіб молодого працездатного віку [1][2][3]. Згідно з сучасними уявленнями, процес ремоделювання кістки залежить від кісткової резорбції і від темпу кісткоутворення та здатності остеобластів формувати повноцінну нову кістку, що безпосередньо пов'язано зі станом метаболізму кісткової тканини і кальцій-фосфорного гомеостазу [4].…”

Intensity and duration of phases of wound healing after surgical intervention in сases of spontaneous periodontitis accompanied by various reactivity of the body

“…In connection with the above, the search for new tools, methods and approaches to the comprehensive treatment of generalized periodontitis remains relevant [10,11]. General and local drug therapy has been widely used in the complex treatment of this pathology [12,13]. The correctness of this tactic is confirmed by numerous data from the literature on the high clinical effectiveness of the proposed and implemented drug treatment regimens for generalized periodontitis.…”