Pathogenic and pathological characteristic of new type gosling viral enteritis first observed in China

Cheng, Anchun; Wang, Mingshu; Chen, Xiaoyue; Guo, Yu-Fei; Liu, Zhaoyu; Fang, Pengfei

doi:10.3748/wjg.v7.i5.678

Cited by 21 publications

(14 citation statements)

References 43 publications

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Section: Introductionmentioning

confidence: 99%

“…The new type gosling viral enteritis (NGVE) is a new infectious disease and firstly recognized by Cheng et al, and it was observed in goslings less than 30 d of age in various areas of Sichuan Province [17,18] . The mortality from acute NGVE is high, and it is clinically characterized by respiratory, digestive, and neurological symptoms and www.wjgnet.com sudden death [17][18][19] . Catarrhal hemorrhagic fibrinonecrotic enteritis of the small intestine and coagulative embolus in the lower middle part of the intestine are the typical pathological changes of the NGVE in infected goslings [18] .…”

Section: Introductionmentioning

confidence: 99%

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Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling

Chen¹,

Cheng²,

Wang³

et al. 2008

WJG

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146

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling

Chen¹,

Cheng²,

Wang³

et al. 2008

WJG

Self Cite

146

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“…The minimal lethal dose of the virus suspension (LD 50 ) was 10 6.5±1.3 /0.5 mL. This strain has been previously described [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Experimental Goslings and Virus Strainmentioning

confidence: 99%

“…An increasing number of viruses or viral gene products have been reported to induce apoptosis [17,22,26,30]. New type gosling viral enteritis (NGVE) is an infectious disease that affects goslings less than 30 days of age, and is caused by an adenovirus called the NGVE virus (NGVEV) [4,5,12,13,15,27,40]. In gosling-producing areas, NGVE has resulted in significant economic losses due to the high mortality of the offspring of breeder geese [12,27].…”

Section: Introductionmentioning

confidence: 99%

Apoptosis inducedin vivoby new type gosling viral enteritis virus

et al. 2011

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In this study, apoptosis was induced by new type gosling viral enteritis virus (NGVEV) in experimentally infected goslings is reported in detail for the first time. After 3-day-old goslings were orally inoculated with a NGVEV-CN strain suspension, the time course of NGVEV effects on apoptotic morphological changes of the internal tissues was evaluated. These changes were observed by histological analysis with light microscopy and ultrastructural analysis with transmission electron microscopy. DNA fragmentation was assessed with a terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay and DNA ladder analysis. A series of characteristic apoptotic morphological changes including chromatin condensation and margination, cytoplasmic shrinkage, plasma membrane blebbing, and formation of apoptotic bodies were noted. Apoptosis was readily observed in the lymphoid and gastrointestinal organs, and sporadically occurred in other organs after 3 days post-infection (PI). The presence and quantity of TUNEL-positive cells increased with infection time until 9 days PI. DNA extracted from the NGVEV-infected gosling cells displayed characteristic 180~200 bp ladders. Apoptotic cells were ubiquitously distributed, especially among lymphocytes, macrophages, monocytes, and epithelial and intestinal cells. Necrosis was subsequently detected during the late NGVEV-infection phase, which was characterized by cell swelling, plasma membrane collapse, and rapidly lysis. Our results suggested that apoptosis may play an important role in the pathogenesis of NGVE disease.

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“…Adenovirus infection of the kidney is seen in a variety of birds [29,30]. Grossly there may be some nonspecific renal enlargement.…”

Section: Viralmentioning

confidence: 99%

Types of Renal Disease in Avian Species

Schmidt¹

2006

Veterinary Clinics of North America: Exotic Animal Practice

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Renal disease in birds is frequently encountered. Like most other animals, birds are susceptible to a full spectrum of renal insults,such as toxins, tumors, infections, and degenerative conditions. Accurate diagnosis of renal disease is based on a complete history,physical examination, and laboratory evaluation of the patient. Because it is often required for a more definitive diagnosis, special attention is given to histopathologic evaluation of renal tissue,whether through a premortem biopsy or collection at gross necropsy.

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Pathogenic and pathological characteristic of new type gosling viral enteritis first observed in China

Abstract: AIM To study the purifying method and characteristics of new gosling viral enteritis virus (NGVEV), the etiological agent of new gosling viral enteritis (NGVE) which was first recognized in China, as well as the pathomorphological development in goslings infected artificially with NGVEV.

Cited by 21 publications

References 43 publications

Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling

Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling

Apoptosis inducedin vivoby new type gosling viral enteritis virus

Types of Renal Disease in Avian Species

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